Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis
We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bo...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2010/161454 |
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| author | Mahesh Bandara David B. Seder George Garratty Regina M. Leger Jonathan B. Zuckerman |
| author_facet | Mahesh Bandara David B. Seder George Garratty Regina M. Leger Jonathan B. Zuckerman |
| author_sort | Mahesh Bandara |
| collection | DOAJ |
| description | We report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF. |
| format | Article |
| id | doaj-art-227cb780518a49fd819e9793dc5584d2 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-227cb780518a49fd819e9793dc5584d22025-02-03T05:51:53ZengWileyCase Reports in Medicine1687-96271687-96352010-01-01201010.1155/2010/161454161454Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic FibrosisMahesh Bandara0David B. Seder1George Garratty2Regina M. Leger3Jonathan B. Zuckerman4Department of Medicine, University of Vermont and Maine Medical Center, 22 Bramhall St., Portland, ME 04102, USADepartment of Medicine, University of Vermont and Maine Medical Center, 22 Bramhall St., Portland, ME 04102, USAAmerican Red Cross Blood Services, Southern California Region, Pomona, CA 91768, USAAmerican Red Cross Blood Services, Southern California Region, Pomona, CA 91768, USADepartment of Medicine, University of Vermont and Maine Medical Center, 22 Bramhall St., Portland, ME 04102, USAWe report a case of drug-induced immune hemolytic anemia (DIIHA) in an adult female with cystic fibrosis (CF), complicating routine treatment of a pulmonary exacerbation with intravenous piperacillin-tazobactam. Workup revealed a positive direct antiglobulin test (DAT) due to red blood cell (RBC)-bound IgG and C3 and piperacillin antibodies detectable in the patient's serum. The potential influence of CF transmembrane conductance regulator mutations on the severity of DIIHA is discussed. This report illustrates the importance of early identification of DIIHA, a rare complication of a commonly utilized medication in CF.http://dx.doi.org/10.1155/2010/161454 |
| spellingShingle | Mahesh Bandara David B. Seder George Garratty Regina M. Leger Jonathan B. Zuckerman Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis Case Reports in Medicine |
| title | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
| title_full | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
| title_fullStr | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
| title_full_unstemmed | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
| title_short | Piperacillin-Induced Immune Hemolytic Anemia in an Adult with Cystic Fibrosis |
| title_sort | piperacillin induced immune hemolytic anemia in an adult with cystic fibrosis |
| url | http://dx.doi.org/10.1155/2010/161454 |
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