The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice

The N-acetyltransferase 10 inhibitor [11C]remodelin: synthesis and preliminary positron emission tomography study in mice

Abstract Background 4-(4-Cyanophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole (remodelin) is a potent N-acetyltransferase 10 (NAT10) inhibitor. This compound inhibits tumors and weakens tumor resistance to antitumor drugs. Moreover, remodelin has been found to enhance healthspan in an animal model...

Full description

Saved in:
Bibliographic Details
Main Authors: Rui Luo, Yiding Zhang, Katsushi Kumata, Lin Xie, Yusuke Kurihara, Masanao Ogawa, Tomomi Kokufuta, Nobuki Nengaki, Feng Wang, Ming-Rong R. Zhang
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
[11C]remodelin, Radiosynthesis
Hydrogen [11C]cyanide
Positron emission tomography
Online Access:https://doi.org/10.1186/s41181-025-00330-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items