Effects of proton pump inhibitor (PPI) use on migraine – a critical review
Abstract Background Proton pump inhibitor (PPI) drugs are widely used and are among the most significant achievements of modern pharmacology. Their primary purpose is treating and preventing gastric acid-related disorders. Migraine and PPI intake are prevalent, and many people are affected by both....
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| Language: | English |
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BMC
2025-01-01
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| Series: | The Journal of Headache and Pain |
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| Online Access: | https://doi.org/10.1186/s10194-025-01954-z |
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| author | Viktoria Tischler-Strasser Irma Burdiladze Goncalo Cabral Esme Ekizoglu Olga Grodzka Keshet Pardo Patryk Sochan Laura Zaunandra Antoinette MaassenVanDenBrink Christian Lampl on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) |
| author_facet | Viktoria Tischler-Strasser Irma Burdiladze Goncalo Cabral Esme Ekizoglu Olga Grodzka Keshet Pardo Patryk Sochan Laura Zaunandra Antoinette MaassenVanDenBrink Christian Lampl on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) |
| author_sort | Viktoria Tischler-Strasser |
| collection | DOAJ |
| description | Abstract Background Proton pump inhibitor (PPI) drugs are widely used and are among the most significant achievements of modern pharmacology. Their primary purpose is treating and preventing gastric acid-related disorders. Migraine and PPI intake are prevalent, and many people are affected by both. In the last few years, a potential link between PPI intake and the development of headaches—especially migraine–has come to increased attention. In this review, we critically examine the scientific data concerning the co-occurrence of these two entities. Findings There seems to be a possible link between the use of PPIs and the occurrence of headache, especially migraine, suggesting a pathophysiological connection on several levels. Moreover, PPI use is only partially without side effects, even if these may not occur immediately. Whether the relation is causative or merely co-existential is currently not yet clear. The influence of genetics, environment, gut microbiome, medication intake and evolution of headache is multidirectional. Conclusion A relation between the prevalence of migraine and the use of PPIs on a population and personal level seems likely. Although PPIs have many advantages, they should be prescribed with caution, especially in patients who suffer from headaches and migraine. In this narrative review, we aim to critically evaluate existing data and offer a potential approach to accurately identify any connections and interactions, leading to a better understanding of how these conditions may influence each other. |
| format | Article |
| id | doaj-art-22797284e0a74897a1d736d323ce90a6 |
| institution | Kabale University |
| issn | 1129-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | The Journal of Headache and Pain |
| spelling | doaj-art-22797284e0a74897a1d736d323ce90a62025-02-02T12:34:40ZengBMCThe Journal of Headache and Pain1129-23772025-01-0126111310.1186/s10194-025-01954-zEffects of proton pump inhibitor (PPI) use on migraine – a critical reviewViktoria Tischler-Strasser0Irma Burdiladze1Goncalo Cabral2Esme Ekizoglu3Olga Grodzka4Keshet Pardo5Patryk Sochan6Laura Zaunandra7Antoinette MaassenVanDenBrink8Christian Lampl9on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)Department of Neurology, Koventhospital Barmherzige BrüderDepartment of Neurology, Tbilisi Central HospitalNeurology Department, Hospital de Egas MonizDepartment of Neurology, Istanbul Faculty of MedicineDepartment of Neurology, Faculty of Medicine and Dentistry, Medical University of WarsawDepartment of Neurology, Rabin Medical Center – Beilinson HospitalDepartment of Neurology, Faculty of Medicine and Dentistry, Medical University, Bielanski HospitalNeurology Unit, IRCCS San Raffaele Scientific InstituteDepartment of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus MC University Medical CenterDepartment of Neurology, Koventhospital Barmherzige BrüderAbstract Background Proton pump inhibitor (PPI) drugs are widely used and are among the most significant achievements of modern pharmacology. Their primary purpose is treating and preventing gastric acid-related disorders. Migraine and PPI intake are prevalent, and many people are affected by both. In the last few years, a potential link between PPI intake and the development of headaches—especially migraine–has come to increased attention. In this review, we critically examine the scientific data concerning the co-occurrence of these two entities. Findings There seems to be a possible link between the use of PPIs and the occurrence of headache, especially migraine, suggesting a pathophysiological connection on several levels. Moreover, PPI use is only partially without side effects, even if these may not occur immediately. Whether the relation is causative or merely co-existential is currently not yet clear. The influence of genetics, environment, gut microbiome, medication intake and evolution of headache is multidirectional. Conclusion A relation between the prevalence of migraine and the use of PPIs on a population and personal level seems likely. Although PPIs have many advantages, they should be prescribed with caution, especially in patients who suffer from headaches and migraine. In this narrative review, we aim to critically evaluate existing data and offer a potential approach to accurately identify any connections and interactions, leading to a better understanding of how these conditions may influence each other.https://doi.org/10.1186/s10194-025-01954-zMigraineHeadachePPIGut dysbiosisCytochrome P450 |
| spellingShingle | Viktoria Tischler-Strasser Irma Burdiladze Goncalo Cabral Esme Ekizoglu Olga Grodzka Keshet Pardo Patryk Sochan Laura Zaunandra Antoinette MaassenVanDenBrink Christian Lampl on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) Effects of proton pump inhibitor (PPI) use on migraine – a critical review The Journal of Headache and Pain Migraine Headache PPI Gut dysbiosis Cytochrome P450 |
| title | Effects of proton pump inhibitor (PPI) use on migraine – a critical review |
| title_full | Effects of proton pump inhibitor (PPI) use on migraine – a critical review |
| title_fullStr | Effects of proton pump inhibitor (PPI) use on migraine – a critical review |
| title_full_unstemmed | Effects of proton pump inhibitor (PPI) use on migraine – a critical review |
| title_short | Effects of proton pump inhibitor (PPI) use on migraine – a critical review |
| title_sort | effects of proton pump inhibitor ppi use on migraine a critical review |
| topic | Migraine Headache PPI Gut dysbiosis Cytochrome P450 |
| url | https://doi.org/10.1186/s10194-025-01954-z |
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