Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis

Integrated serum metabolomics and network pharmacology reveal molecular mechanism of Qixue Huazheng formula on peritoneal fibrosis

BackgroundPeritoneal fibrosis (PF) causes peritoneal dialysis (PD) withdrawal due to ultrafiltration failure. Qixue Huazheng formula (QXHZF), comprising Astragalus membranaceus, Centella asiatica, and Ligusticum sinense, is applied to treat PD-related peritoneum injury related; however, the active c...

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Bibliographic Details
Main Authors: Xiaohui Meng, Li Sheng, Yongqing You, Huibo Dai, Manshu Yu, Funing Wang, Ziren Zhou, Yun Shan, Meixiao Sheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
traditional Chinese medicine
Qixue Huazheng formula
peritoneal fibrosis
metabolomics
network pharmacology
estrogen signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1515038/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1515038/full

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