Effect of isavuconazole on the concentration of tacrolimus in a patient with genotype CYP3A5*1/*3: a case report

Effect of isavuconazole on the concentration of tacrolimus in a patient with genotype CYP3A5*1/*3: a case report

Abstract Background Azole antifungals are the standard treatment for pulmonary mycosis, which may develop during long-term immunotherapy for kidney transplant. Isavuconazole (ISCZ) is a cytochrome P450 (CYP) 3 A inhibitor that has a risk of interacting with the immunosuppressive drug tacrolimus (TAC...

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Main Authors: Hayato Yokota, Yumiko Akamine, Harumi Hatakeyama, Hideaki Kagaya, Sho Sakamoto, Mitsuru Saito, Masahide Takeda, Kazuhiro Sato, Katsutoshi Nakayama, Masafumi Kikuchi
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
CYP3A5
Drug–drug interactions
Isavuconazole
Tacrolimus
Therapeutic drug monitoring
Online Access:https://doi.org/10.1186/s40780-025-00427-4
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