Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker
Langerhans cell histiocytosis is characterized by the abnormal nodular proliferation of histiocytes in various organ systems. Pulmonary involvement seen in young adults is nearly always seen in the context of past or current cigarette smoking. Although it tends to be a single-system disease, extrapu...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/3740902 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547064785928192 |
|---|---|
| author | K. Earlam C. A. Souza R. Glikstein M. M. Gomes S. Pakhalé |
| author_facet | K. Earlam C. A. Souza R. Glikstein M. M. Gomes S. Pakhalé |
| author_sort | K. Earlam |
| collection | DOAJ |
| description | Langerhans cell histiocytosis is characterized by the abnormal nodular proliferation of histiocytes in various organ systems. Pulmonary involvement seen in young adults is nearly always seen in the context of past or current cigarette smoking. Although it tends to be a single-system disease, extrapulmonary manifestations involving the skin, bone, and hypothalamic-pituitary-axis are possible. High resolution CT (HRCT) of the thorax findings includes centrilobular nodules and cysts that are bizarre in shape, variable in size, and thin-walled. Often the diagnosis can be made based on the appropriate clinical presentation and typical imaging findings. Treatment includes smoking cessation and the potential use of glucocorticoids or cytotoxic agents depending on the severity of disease and multisystem involvement. |
| format | Article |
| id | doaj-art-2265b1369aff437eb470e1ac7b2f015c |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-2265b1369aff437eb470e1ac7b2f015c2025-02-03T06:46:13ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/37409023740902Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young SmokerK. Earlam0C. A. Souza1R. Glikstein2M. M. Gomes3S. Pakhalé4Division of Respirology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, K1H 8L6, CanadaDepartment of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, ON, K1H 8L6, CanadaDepartment of Medical Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, ON, K1H 8L6, CanadaDepartment of Pathology and Laboratory Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, K1H 8L6, CanadaDivision of Respirology, The Ottawa Hospital, University of Ottawa, Ottawa, ON, K1H 8L6, CanadaLangerhans cell histiocytosis is characterized by the abnormal nodular proliferation of histiocytes in various organ systems. Pulmonary involvement seen in young adults is nearly always seen in the context of past or current cigarette smoking. Although it tends to be a single-system disease, extrapulmonary manifestations involving the skin, bone, and hypothalamic-pituitary-axis are possible. High resolution CT (HRCT) of the thorax findings includes centrilobular nodules and cysts that are bizarre in shape, variable in size, and thin-walled. Often the diagnosis can be made based on the appropriate clinical presentation and typical imaging findings. Treatment includes smoking cessation and the potential use of glucocorticoids or cytotoxic agents depending on the severity of disease and multisystem involvement.http://dx.doi.org/10.1155/2016/3740902 |
| spellingShingle | K. Earlam C. A. Souza R. Glikstein M. M. Gomes S. Pakhalé Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker Canadian Respiratory Journal |
| title | Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker |
| title_full | Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker |
| title_fullStr | Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker |
| title_full_unstemmed | Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker |
| title_short | Pulmonary Langerhans Cell Histiocytosis and Diabetes Insipidus in a Young Smoker |
| title_sort | pulmonary langerhans cell histiocytosis and diabetes insipidus in a young smoker |
| url | http://dx.doi.org/10.1155/2016/3740902 |
| work_keys_str_mv | AT kearlam pulmonarylangerhanscellhistiocytosisanddiabetesinsipidusinayoungsmoker AT casouza pulmonarylangerhanscellhistiocytosisanddiabetesinsipidusinayoungsmoker AT rglikstein pulmonarylangerhanscellhistiocytosisanddiabetesinsipidusinayoungsmoker AT mmgomes pulmonarylangerhanscellhistiocytosisanddiabetesinsipidusinayoungsmoker AT spakhale pulmonarylangerhanscellhistiocytosisanddiabetesinsipidusinayoungsmoker |