Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes
Lipoprotein delivery of fatty acids and cholesterol is linked with peroxisome proliferator-activated receptor (PPAR) activation in adipocytes and macrophages. We postulated that similar interactions exist in sebaceous epithelial cells (sebocytes) in which PPAR activation induces differentiation. Hig...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2011/163631 |
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| author | Dianne Deplewski Kenan Qin Nancy Ciletti Robert L. Rosenfield |
| author_facet | Dianne Deplewski Kenan Qin Nancy Ciletti Robert L. Rosenfield |
| author_sort | Dianne Deplewski |
| collection | DOAJ |
| description | Lipoprotein delivery of fatty acids and cholesterol is linked with peroxisome proliferator-activated receptor (PPAR) activation in adipocytes and macrophages. We postulated that similar interactions exist in sebaceous epithelial cells (sebocytes) in which PPAR activation induces differentiation. High-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) markedly enhanced sebocyte differentiation above that found with PPAR agonists and were more potent than explicable by their lipid content. The PPARγ antagonist GW5393 reduced sebocyte differentiation to all PPAR isoform agonists, HDL and VLDL, suggesting that the lipoprotein effect on differentiation occurs partially through activation of PPARγ. Furthermore, we found that sebocytes expressed a unique pattern of lipogenic genes. Our results demonstrate that HDL and VLDL are the most potent inducers of sebocyte differentiation tested to date, and these actions are partially inhibited by PPAR antagonists. This suggests that substrates provided by lipoproteins are targeted to sebocytes and affect their own disposition via PPAR activation. |
| format | Article |
| id | doaj-art-2262c5c1c50046f3ac1781ce5b522a32 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-2262c5c1c50046f3ac1781ce5b522a322025-02-03T05:59:39ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322011-01-01201110.1155/2011/163631163631Unique Mode of Lipogenic Activation in Rat Preputial SebocytesDianne Deplewski0Kenan Qin1Nancy Ciletti2Robert L. Rosenfield3Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue (MC-5053), Chicago, IL 60637-1470, USADepartment of Pediatrics, Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue (MC-5053), Chicago, IL 60637-1470, USADepartment of Pediatrics, Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue (MC-5053), Chicago, IL 60637-1470, USADepartment of Pediatrics, Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue (MC-5053), Chicago, IL 60637-1470, USALipoprotein delivery of fatty acids and cholesterol is linked with peroxisome proliferator-activated receptor (PPAR) activation in adipocytes and macrophages. We postulated that similar interactions exist in sebaceous epithelial cells (sebocytes) in which PPAR activation induces differentiation. High-density lipoprotein (HDL) and very low-density lipoprotein (VLDL) markedly enhanced sebocyte differentiation above that found with PPAR agonists and were more potent than explicable by their lipid content. The PPARγ antagonist GW5393 reduced sebocyte differentiation to all PPAR isoform agonists, HDL and VLDL, suggesting that the lipoprotein effect on differentiation occurs partially through activation of PPARγ. Furthermore, we found that sebocytes expressed a unique pattern of lipogenic genes. Our results demonstrate that HDL and VLDL are the most potent inducers of sebocyte differentiation tested to date, and these actions are partially inhibited by PPAR antagonists. This suggests that substrates provided by lipoproteins are targeted to sebocytes and affect their own disposition via PPAR activation.http://dx.doi.org/10.1155/2011/163631 |
| spellingShingle | Dianne Deplewski Kenan Qin Nancy Ciletti Robert L. Rosenfield Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes Journal of Nutrition and Metabolism |
| title | Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes |
| title_full | Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes |
| title_fullStr | Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes |
| title_full_unstemmed | Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes |
| title_short | Unique Mode of Lipogenic Activation in Rat Preputial Sebocytes |
| title_sort | unique mode of lipogenic activation in rat preputial sebocytes |
| url | http://dx.doi.org/10.1155/2011/163631 |
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