Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer
Photodynamic therapy (PDT) is a noninvasive procedure involving a photosensitizing agent that is activated by light to produce reactive oxygen species (ROS) that selectively destroy tumor cells. In recent years, PDT has been used in the treatment of pancreatic cancer (PC). The antitumor effects of P...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Photoenergy |
| Online Access: | http://dx.doi.org/10.1155/2012/637429 |
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| _version_ | 1832559746222129152 |
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| author | Wei Li Qingyong Ma Erxi Wu |
| author_facet | Wei Li Qingyong Ma Erxi Wu |
| author_sort | Wei Li |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a noninvasive procedure involving a photosensitizing agent that is activated by light to produce reactive oxygen species (ROS) that selectively destroy tumor cells. In recent years, PDT has been used in the treatment of pancreatic cancer (PC). The antitumor effects of PDT include three main mechanisms: direct tumor cell death (necrosis, apoptosis, and autophagy), vascular destruction, and immune system activation. The present paper systematically summarizes the effects of PDT in the treatment of PC from the experimental studies to the clinical studies and discusses the mechanisms of PDT-induced PC destruction. |
| format | Article |
| id | doaj-art-2254454528e149cfb646b104f73a256a |
| institution | Kabale University |
| issn | 1110-662X 1687-529X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Photoenergy |
| spelling | doaj-art-2254454528e149cfb646b104f73a256a2025-02-03T01:29:17ZengWileyInternational Journal of Photoenergy1110-662X1687-529X2012-01-01201210.1155/2012/637429637429Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic CancerWei Li0Qingyong Ma1Erxi Wu2Department of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, Shaanxi Province, ChinaDepartment of Hepatobiliary Surgery, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 West Yanta Road, Xi'an 710061, Shaanxi Province, ChinaDepartment of Pharmaceutical Sciences, North Dakota State University, Sudro Hall 203, Fargo, ND 58105, USAPhotodynamic therapy (PDT) is a noninvasive procedure involving a photosensitizing agent that is activated by light to produce reactive oxygen species (ROS) that selectively destroy tumor cells. In recent years, PDT has been used in the treatment of pancreatic cancer (PC). The antitumor effects of PDT include three main mechanisms: direct tumor cell death (necrosis, apoptosis, and autophagy), vascular destruction, and immune system activation. The present paper systematically summarizes the effects of PDT in the treatment of PC from the experimental studies to the clinical studies and discusses the mechanisms of PDT-induced PC destruction.http://dx.doi.org/10.1155/2012/637429 |
| spellingShingle | Wei Li Qingyong Ma Erxi Wu Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer International Journal of Photoenergy |
| title | Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer |
| title_full | Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer |
| title_fullStr | Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer |
| title_full_unstemmed | Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer |
| title_short | Perspectives on the Role of Photodynamic Therapy in the Treatment of Pancreatic Cancer |
| title_sort | perspectives on the role of photodynamic therapy in the treatment of pancreatic cancer |
| url | http://dx.doi.org/10.1155/2012/637429 |
| work_keys_str_mv | AT weili perspectivesontheroleofphotodynamictherapyinthetreatmentofpancreaticcancer AT qingyongma perspectivesontheroleofphotodynamictherapyinthetreatmentofpancreaticcancer AT erxiwu perspectivesontheroleofphotodynamictherapyinthetreatmentofpancreaticcancer |