FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents
Purpose. The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there w...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2018/3134026 |
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| author | Gabrielle Araujo do Nascimento Neiva Leite Lupe Furtado-Alle Mayza Dalcin Teixeira Ricardo Lehtonen Rodrigues de Souza Gerusa Eisfeld Milano Larissa Rosa da Silva Juliana Pizzi Wendell Arthur Lopes Maria de Fátima Aguiar Lopes Ana Cláudia Kapp Titski Luciane Viater Tureck |
| author_facet | Gabrielle Araujo do Nascimento Neiva Leite Lupe Furtado-Alle Mayza Dalcin Teixeira Ricardo Lehtonen Rodrigues de Souza Gerusa Eisfeld Milano Larissa Rosa da Silva Juliana Pizzi Wendell Arthur Lopes Maria de Fátima Aguiar Lopes Ana Cláudia Kapp Titski Luciane Viater Tureck |
| author_sort | Gabrielle Araujo do Nascimento |
| collection | DOAJ |
| description | Purpose. The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables. Methods. The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. Results. The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p=0.03) and HOMA (p=0.007) and lower levels of glucose (p=0.003), but the SNP did not modulate the response to physical exercise. Conclusions. In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise. |
| format | Article |
| id | doaj-art-2248359493124c02a7c0a357ffdd1765 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-2248359493124c02a7c0a357ffdd17652025-02-03T01:23:23ZengWileyJournal of Obesity2090-07082090-07162018-01-01201810.1155/2018/31340263134026FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese AdolescentsGabrielle Araujo do Nascimento0Neiva Leite1Lupe Furtado-Alle2Mayza Dalcin Teixeira3Ricardo Lehtonen Rodrigues de Souza4Gerusa Eisfeld Milano5Larissa Rosa da Silva6Juliana Pizzi7Wendell Arthur Lopes8Maria de Fátima Aguiar Lopes9Ana Cláudia Kapp Titski10Luciane Viater Tureck11Department of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, BrazilDepartment of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, BrazilDepartment of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, BrazilDepartment of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, BrazilDepartment of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, BrazilDepartment of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, BrazilDepartment of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, BrazilDepartment of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, BrazilDepartment of Physical Education, State University of Maringa, Av. Colombo 5790, 87020-900 Maringa, PR, BrazilDepartment of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, BrazilDepartment of Physical Education, Federal University of Paraná, Coração de Maria, 92 Jardim Botânico, 80215-370 Curitiba, PR, BrazilDepartment of Genetics, Centro Politécnico, Setor de Ciências Biológicas, Federal University of Paraná, Francisco H. dos Santos, 210 Jardim das Américas, 81531-970 Curitiba, PR, BrazilPurpose. The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes. The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables. Methods. The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks. All were genotyped by TaqMan SNP genotyping assay. Results. The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p=0.03) and HOMA (p=0.007) and lower levels of glucose (p=0.003), but the SNP did not modulate the response to physical exercise. Conclusions. In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.http://dx.doi.org/10.1155/2018/3134026 |
| spellingShingle | Gabrielle Araujo do Nascimento Neiva Leite Lupe Furtado-Alle Mayza Dalcin Teixeira Ricardo Lehtonen Rodrigues de Souza Gerusa Eisfeld Milano Larissa Rosa da Silva Juliana Pizzi Wendell Arthur Lopes Maria de Fátima Aguiar Lopes Ana Cláudia Kapp Titski Luciane Viater Tureck FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents Journal of Obesity |
| title | FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents |
| title_full | FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents |
| title_fullStr | FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents |
| title_full_unstemmed | FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents |
| title_short | FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents |
| title_sort | fto rs9939609 does not interact with physical exercise but influences basal insulin metabolism in brazilian overweight and obese adolescents |
| url | http://dx.doi.org/10.1155/2018/3134026 |
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