The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms
Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this st...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/259412 |
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| author | Shumei Jin Mixia Zhang Yan Gao Xuebin Zhang Guangzhi Cui Yanjun Zhang |
| author_facet | Shumei Jin Mixia Zhang Yan Gao Xuebin Zhang Guangzhi Cui Yanjun Zhang |
| author_sort | Shumei Jin |
| collection | DOAJ |
| description | Jing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA. |
| format | Article |
| id | doaj-art-2240285ed81c48f1b1d32f1e46953040 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2240285ed81c48f1b1d32f1e469530402025-02-03T01:31:08ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/259412259412The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its MechanismsShumei Jin0Mixia Zhang1Yan Gao2Xuebin Zhang3Guangzhi Cui4Yanjun Zhang5Tianjin Huanhu Hospital, Tianjin 300060, ChinaChinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaTianjin Children’s Hospital, Tianjin 300074, ChinaTianjin Huanhu Hospital, Tianjin 300060, ChinaChinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaChinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, No. 312 Anshanxi Road, Nankai District, Tianjin 300193, ChinaJing Wan Hong ointment contains 30 kinds of Chinese herbs, with functions of activating blood circulation to disperse blood stasis, clearing heat, eliminating dampness, and reducing swelling by detoxification. Therefore, Jing Wan Hong ointment may facilitate the healing of ulcers. The aim of this study was to evaluate the efficacy and mechanisms of Jing Wan Hong ointment for healing diabetic foot ulceration in Wistar rats induced by streptozotocin and sciatic nerve damage. The results showed that Jing Wan Hong ointment had a marked effect on foot ulcers in diabetic rats induced by initial nerve injury. These effects were manifested by reducing the foot ulcer size and Wagner grade after seven days of treatment. The diabetic rats with foot ulcers were almost healed after 21 days of treatment. Moreover, the mechanisms of this effect seem to be dependent on increased expression of PDGF mRNA, but there was no influence on the expression of TGF-β, VEGF, and FLT-1 mRNA.http://dx.doi.org/10.1155/2014/259412 |
| spellingShingle | Shumei Jin Mixia Zhang Yan Gao Xuebin Zhang Guangzhi Cui Yanjun Zhang The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms Journal of Diabetes Research |
| title | The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms |
| title_full | The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms |
| title_fullStr | The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms |
| title_full_unstemmed | The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms |
| title_short | The Efficacy of Jing Wan Hong Ointment for Nerve Injury Diabetic Foot Ulcer and Its Mechanisms |
| title_sort | efficacy of jing wan hong ointment for nerve injury diabetic foot ulcer and its mechanisms |
| url | http://dx.doi.org/10.1155/2014/259412 |
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