The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective
Gastroesophageal airway reflux disease (GARD) refers to a class of diseases in which the contents of the digestive system reflux into esophagus, the upper and lower airways, mouth, ear and nose et al., causing uncomfortable symptoms. It covers gastroesophageal reflux disease and extra-esophageal ref...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-01-01
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| Series: | Gastroenterology & Endoscopy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949752324000669 |
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| author | Sheng Chen Min Wang Shuai Zhang Xin Huang Xinke Sui Dou Li Changqing Zhong Wei Wu |
| author_facet | Sheng Chen Min Wang Shuai Zhang Xin Huang Xinke Sui Dou Li Changqing Zhong Wei Wu |
| author_sort | Sheng Chen |
| collection | DOAJ |
| description | Gastroesophageal airway reflux disease (GARD) refers to a class of diseases in which the contents of the digestive system reflux into esophagus, the upper and lower airways, mouth, ear and nose et al., causing uncomfortable symptoms. It covers gastroesophageal reflux disease and extra-esophageal reflux disease. GARD is one of the most common diseases in clinical practice. The main cause of GARD-related clinical symptoms and signs of GARD is the structural damage and functional disability, which were caused by repeated contact between the mucous epithelium of the reflux tract and the acidic and non-acidic components of the reflux. Over the years, major progress has been made in the understanding of the molecular pathogenesis of reflux associated mucosal inflammation, suggesting a complex and multifactorial pathogenesis and immune-mediated effects. Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. New drug therapies for the mucosal injuries in the reflux tract were also reviewed. From bench to bedside, these novel molecular findings might provide new perspectives and therapeutic approaches for GARD. |
| format | Article |
| id | doaj-art-22401224b04b4efeac3ada29d8228330 |
| institution | Kabale University |
| issn | 2949-7523 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Gastroenterology & Endoscopy |
| spelling | doaj-art-22401224b04b4efeac3ada29d82283302025-01-20T04:18:07ZengKeAi Communications Co., Ltd.Gastroenterology & Endoscopy2949-75232025-01-01313946The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspectiveSheng Chen0Min Wang1Shuai Zhang2Xin Huang3Xinke Sui4Dou Li5Changqing Zhong6Wei Wu7Department of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR ChinaDepartment of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR ChinaDepartment of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR ChinaDepartment of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR ChinaDepartment of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR ChinaDepartment of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR ChinaDepartment of Gastroenterology, Ninth Medical Center of Chinese PLA General Hospital, PR China; Corresponding author. No.9 Anxiang North Lane, Chaoyang District, Beijing, 10010, PR China.Department of Otolaryngology, Ninth Medical Center of Chinese PLA General Hospital, PR China; Corresponding author. No.9 Anxiang North Lane, Chaoyang District, Beijing, 10010, PR China.Gastroesophageal airway reflux disease (GARD) refers to a class of diseases in which the contents of the digestive system reflux into esophagus, the upper and lower airways, mouth, ear and nose et al., causing uncomfortable symptoms. It covers gastroesophageal reflux disease and extra-esophageal reflux disease. GARD is one of the most common diseases in clinical practice. The main cause of GARD-related clinical symptoms and signs of GARD is the structural damage and functional disability, which were caused by repeated contact between the mucous epithelium of the reflux tract and the acidic and non-acidic components of the reflux. Over the years, major progress has been made in the understanding of the molecular pathogenesis of reflux associated mucosal inflammation, suggesting a complex and multifactorial pathogenesis and immune-mediated effects. Thus, we reviewed the clinical and pathophysiological characteristics of GARD and probe the complexity of the pathogenesis of GARD-related mucosal inflammation from the aspects of microscopic changes and specific molecular mediators. New drug therapies for the mucosal injuries in the reflux tract were also reviewed. From bench to bedside, these novel molecular findings might provide new perspectives and therapeutic approaches for GARD.http://www.sciencedirect.com/science/article/pii/S2949752324000669Gastroesophageal airway reflux diseaseInflammatory lesions of the mucosaMolecular biological mechanisms |
| spellingShingle | Sheng Chen Min Wang Shuai Zhang Xin Huang Xinke Sui Dou Li Changqing Zhong Wei Wu The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective Gastroenterology & Endoscopy Gastroesophageal airway reflux disease Inflammatory lesions of the mucosa Molecular biological mechanisms |
| title | The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective |
| title_full | The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective |
| title_fullStr | The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective |
| title_full_unstemmed | The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective |
| title_short | The complexity of mucosal damage in gastroesophageal airway reflux disease: A molecular perspective |
| title_sort | complexity of mucosal damage in gastroesophageal airway reflux disease a molecular perspective |
| topic | Gastroesophageal airway reflux disease Inflammatory lesions of the mucosa Molecular biological mechanisms |
| url | http://www.sciencedirect.com/science/article/pii/S2949752324000669 |
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