Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles

The Flower protein was suggested to couple the fusion of synaptic vesicles (SVs) to their recycling in different model organisms. It is supposed to trigger activity-dependent bulk endocytosis by conducting Ca2+ at endocytic sites. However, this mode of action is debated. Here, we investigated the ro...

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Bibliographic Details
Main Authors: Marius Seidenthal, Jasmina Redzovic, Jana F Liewald, Dennis Rentsch, Stepan Shapiguzov, Noah Schuh, Nils Rosenkranz, Stefan Eimer, Alexander Gottschalk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
plasma membran Ca2+ ATPase
synaptic vesicle recycling
Ca2+ homeostasis
PIP2
endocytosis
Online Access:https://elifesciences.org/articles/103870
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