Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease

Human ACE2 transgenic pigs are susceptible to SARS-CoV-2 and develop COVID-19-like disease

Abstract Animal models that accurately reflect COVID-19 are vital for understanding mechanisms of disease and advancing development of improved vaccines and therapeutics. Pigs are increasingly recognized as valuable models for human disease due to their genetic, anatomical, physiological, and immuno...

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Main Authors: Long Fung Chau, Simon Lillico, Tanja Opriessnig, Rosemary Blake, Luc Tardy, Chen-Hsuin Lee, Scott Maxwell, Claire Warren, Elizabeth Thornton, Catherine L. Mclaughlin, Gerry McLachlan, Christine Tait-Burkard, Sarah Fletcher, Stephen Anderson, Sharon Brown, Louise Gibbard, Thomas Tzelos, Dawn MacMillan-Christensen, J. Kenneth Baillie, David A. Dorward, David J. Griffiths, Finn Grey
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54615-1
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