Bivalent Inhibitors of Mannose-Specific Bacterial Adhesion: A Xylose-Based Conformational Switch to Control Glycoligand Distance

Bivalent Inhibitors of Mannose-Specific Bacterial Adhesion: A Xylose-Based Conformational Switch to Control Glycoligand Distance

Functional glycomimetics is suited to study the parameters of carbohydrate recognition that forms the basis of glycobiology. It is particularly attractive when a glycoligand allows for the investigation of two different states, such as varying distance between multiple glycoligands. Here, a xylopyra...

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Bibliographic Details
Main Authors: Sven Ole Jaeschke, Ingo vom Sondern, Thisbe K. Lindhorst
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
carbohydrate chemistry
carbohydrate recognition
conformational switch
bacterial adhesion
FimH
lectin inhibitors
Online Access:https://www.mdpi.com/1420-3049/30/15/3074
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