Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma
Pancreatic adenocarcinoma remains a cancer associated with a poor prognosis. For locally advanced pancreatic cancer (LAPC), median overall survival is approximately 16 months. Here we report the case of a 52-year-old LAPC patient treated with chemotherapy followed by chemoradiotherapy that was assoc...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/8598635 |
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| _version_ | 1832550196636024832 |
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| author | Marion Alhenc-Gelas Romain Cohen Pascale Cervera Jean-Christophe Vaillant Thierry André |
| author_facet | Marion Alhenc-Gelas Romain Cohen Pascale Cervera Jean-Christophe Vaillant Thierry André |
| author_sort | Marion Alhenc-Gelas |
| collection | DOAJ |
| description | Pancreatic adenocarcinoma remains a cancer associated with a poor prognosis. For locally advanced pancreatic cancer (LAPC), median overall survival is approximately 16 months. Here we report the case of a 52-year-old LAPC patient treated with chemotherapy followed by chemoradiotherapy that was associated with a 14-year complete remission. A peritoneal relapse was then observed and chemotherapy was undergone until the patient died of infectious complications, 17 years after his diagnosis. The tumor was found KRAS, TP53, BRCA1, and BRCA2 wild-type. This KRAS wild-type LAPC-long survivor case report emphasizes the need to develop molecular approaches to predict LAPC patients’ prognosis. |
| format | Article |
| id | doaj-art-21f717e5f6b146988c34f08f237f4a5b |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-21f717e5f6b146988c34f08f237f4a5b2025-02-03T06:07:23ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362019-01-01201910.1155/2019/85986358598635Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic AdenocarcinomaMarion Alhenc-Gelas0Romain Cohen1Pascale Cervera2Jean-Christophe Vaillant3Thierry André4Sorbonne Université, Department of Medical Oncology, AP-HP, Hôpital Saint-Antoine, F-75012 Paris, FranceSorbonne Université, Department of Medical Oncology, AP-HP, Hôpital Saint-Antoine, F-75012 Paris, FranceSorbonne Université, Department of Pathology, AP-HP, Hôpital Saint-Antoine, F-75012 Paris, FranceSorbonne Université, Department of Digestive and Hepatobiliary Surgery, AP-HP, Pitié-Salpêtrière Hospital, F-75013 Paris, FranceSorbonne Université, Department of Medical Oncology, AP-HP, Hôpital Saint-Antoine, F-75012 Paris, FrancePancreatic adenocarcinoma remains a cancer associated with a poor prognosis. For locally advanced pancreatic cancer (LAPC), median overall survival is approximately 16 months. Here we report the case of a 52-year-old LAPC patient treated with chemotherapy followed by chemoradiotherapy that was associated with a 14-year complete remission. A peritoneal relapse was then observed and chemotherapy was undergone until the patient died of infectious complications, 17 years after his diagnosis. The tumor was found KRAS, TP53, BRCA1, and BRCA2 wild-type. This KRAS wild-type LAPC-long survivor case report emphasizes the need to develop molecular approaches to predict LAPC patients’ prognosis.http://dx.doi.org/10.1155/2019/8598635 |
| spellingShingle | Marion Alhenc-Gelas Romain Cohen Pascale Cervera Jean-Christophe Vaillant Thierry André Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma Case Reports in Gastrointestinal Medicine |
| title | Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma |
| title_full | Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma |
| title_fullStr | Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma |
| title_full_unstemmed | Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma |
| title_short | Long-Term Survival in Locally Advanced KRAS Wild-Type Pancreatic Adenocarcinoma |
| title_sort | long term survival in locally advanced kras wild type pancreatic adenocarcinoma |
| url | http://dx.doi.org/10.1155/2019/8598635 |
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