3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment
The past few decades have shown significant advancement as complex in vitro humanized systems have substituted animal trials and 2D in vitro studies. 3D humanized platforms mimic the organs of interest with their stimulations (physical, electrical, chemical, and mechanical). Organ-on-chip devices, i...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Polymer Technology |
| Online Access: | http://dx.doi.org/10.1155/2020/6187048 |
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| _version_ | 1832554549702819840 |
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| author | Aida Rodriguez-Garcia Jacqueline Oliva-Ramirez Claudia Bautista-Flores Samira Hosseini |
| author_facet | Aida Rodriguez-Garcia Jacqueline Oliva-Ramirez Claudia Bautista-Flores Samira Hosseini |
| author_sort | Aida Rodriguez-Garcia |
| collection | DOAJ |
| description | The past few decades have shown significant advancement as complex in vitro humanized systems have substituted animal trials and 2D in vitro studies. 3D humanized platforms mimic the organs of interest with their stimulations (physical, electrical, chemical, and mechanical). Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment. In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment. The current strategies, fabrication methods, and the specific application of each device, as well as the advantages and disadvantages, are presented for each reported platform. This comprehensive review also provides some insights on the challenges and future perspectives for the further advancement of each organ-on-chip device. |
| format | Article |
| id | doaj-art-21f18cc0e49d48998dc6598584a24101 |
| institution | Kabale University |
| issn | 0730-6679 1098-2329 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Polymer Technology |
| spelling | doaj-art-21f18cc0e49d48998dc6598584a241012025-02-03T05:51:13ZengWileyAdvances in Polymer Technology0730-66791098-23292020-01-01202010.1155/2020/618704861870483D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and AssessmentAida Rodriguez-Garcia0Jacqueline Oliva-Ramirez1Claudia Bautista-Flores2Samira Hosseini3Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, Instituto de Biotecnología, Ave. Pedro de Alba S/N, Ciudad Universitaria, CP 66455, San Nicolás de los Garza, NL, MexicoTecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Lago de Guadalupe Km 3.5, Cd López Mateos, Atizapán, Estado de Mexico, MexicoTecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey, 64849 NL, MexicoTecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Ave. Eugenio Garza Sada 2501, Monterrey, 64849 NL, MexicoThe past few decades have shown significant advancement as complex in vitro humanized systems have substituted animal trials and 2D in vitro studies. 3D humanized platforms mimic the organs of interest with their stimulations (physical, electrical, chemical, and mechanical). Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment. In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment. The current strategies, fabrication methods, and the specific application of each device, as well as the advantages and disadvantages, are presented for each reported platform. This comprehensive review also provides some insights on the challenges and future perspectives for the further advancement of each organ-on-chip device.http://dx.doi.org/10.1155/2020/6187048 |
| spellingShingle | Aida Rodriguez-Garcia Jacqueline Oliva-Ramirez Claudia Bautista-Flores Samira Hosseini 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment Advances in Polymer Technology |
| title | 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment |
| title_full | 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment |
| title_fullStr | 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment |
| title_full_unstemmed | 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment |
| title_short | 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment |
| title_sort | 3d in vitro human organ mimicry devices for drug discovery development and assessment |
| url | http://dx.doi.org/10.1155/2020/6187048 |
| work_keys_str_mv | AT aidarodriguezgarcia 3dinvitrohumanorganmimicrydevicesfordrugdiscoverydevelopmentandassessment AT jacquelineolivaramirez 3dinvitrohumanorganmimicrydevicesfordrugdiscoverydevelopmentandassessment AT claudiabautistaflores 3dinvitrohumanorganmimicrydevicesfordrugdiscoverydevelopmentandassessment AT samirahosseini 3dinvitrohumanorganmimicrydevicesfordrugdiscoverydevelopmentandassessment |