The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

Progression through the G1 phase of the cell cycle is the most highly regulated step in cellular division. We employed a chemogenetic approach to discover novel cellular networks that regulate cell cycle progression. This approach uncovered functional clusters of genes that altered sensitivity of ce...

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Bibliographic Details
Main Authors: Adam D Longhurst, Kyle Wang, Harsha Garadi Suresh, Mythili Ketavarapu, Henry N Ward, Ian R Jones, Vivek Narayan, Frances V Hundley, Arshia Zernab Hassan, Charles Boone, Chad L Myers, Yin Shen, Vijay Ramani, Brenda J Andrews, David P Toczyski
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
molecular biology
cell cycle
D-type cyclins
palbociclib
Online Access:https://elifesciences.org/articles/97577
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