Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing

Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing

Abstract Background Cholesterol metabolism plays a significant role in cancer progression, including prostate adenocarcinoma (PRAD), making it a promising target for therapeutic intervention. This study aimed to construct and validate a cholesterol metabolism gene (CMG)-related prognostic signature...

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Bibliographic Details
Main Authors: Zixiong Jiang, Yu Luo, Liangdong Song, Jindong Zhang, Chengcheng Wei, Shuai Su, Delin Wang
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Discover Oncology
Subjects:
Prostate adenocarcinoma
Cholesterol metabolism
Prognostic signature
Machine learning
Single-cell sequencing
Online Access:https://doi.org/10.1007/s12672-025-03294-5
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