Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: a targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammation in rats

Innovative pH-responsive alginate-coated rosuvastatin-loaded chitosan nanoparticles: a targeted approach to inhibiting HMGB1-activated RAGE/TLR4-NFκB signaling in colonic inflammation in rats

This study developed and optimized an innovative oral pH-dependent drug delivery system utilizing rosuvastatin-loaded chitosan nanoparticles (RSV-CSNPs) coated with sodium alginate (ALG). The goal was to protect RSV-CSNPs from degradation in the acidic gastric environment and facilitate targeted sus...

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Main Authors: Elsayed A. Elmorsy, Sameh Saber, Zubida M. Al-Majdoub, Rabab S. Hamad, Mustafa Ahmed Abdel-Reheim, Asmaa Ramadan, Norah Suliman Alsoqih, Mariam S. Alharbi, Hamad Alsaykhan, Alshaimaa A. Farrag, Hanan Eissa, Rasha Abdelhady, Abousree T. Ellethy, Mostafa M. Khodeir, Hossam A. Elsisi, Syed Suhail Ahmed, Ahmed Y. Kira
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
rosuvastatin/pH-responsive nanoparticles
inflammation
colonic delivery system/colitis
sodium alginate/chitosan nanoparticles
HMGB1-RAGE/TLR4-NFκB
DSS/Sprague-Dawley rat colitis model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1546010/full
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