Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Background: To explore the association between gamma-glutamyltransferase (GGT) and in-hospital heart failure (HF) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI)....
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25005 |
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| author | An-Cheng Hou Jian-Tong Hou Wei-Ning Zhou Yan-Jin Wei Zhi-Hong Ou Cun-Fei Liu |
| author_facet | An-Cheng Hou Jian-Tong Hou Wei-Ning Zhou Yan-Jin Wei Zhi-Hong Ou Cun-Fei Liu |
| author_sort | An-Cheng Hou |
| collection | DOAJ |
| description | Background: To explore the association between gamma-glutamyltransferase (GGT) and in-hospital heart failure (HF) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 412 patients diagnosed with STEMI and treated with primary PCI were included in our study. Univariate and multivariate logistic regression models were used to evaluate the association between GGT and the risk of in-hospital HF in STEMI patients. The receiver operating characteristic (ROC) curve was used to assess the accuracy of GGT in predicting in-hospital HF. Results: The incidence of HF after STEMI increased significantly with increasing GGT tertiles (the first, second, and third tertile groups were 7.97%, 14.49%, and 18.38%, respectively; p = 0.039). Multivariate logistic regression analysis revealed that the risk of HF in the second and third GGT tertile groups was 2.51 times greater (95% CI, 1.06–5.96) and 2.77 times greater (95% CI, 1.13–6.81), respectively, than that in the first GGT tertile group. Each 1-unit increase in the lnGGT level was related to a 1.88-fold increased risk of HF (odds ratio, OR, 1.88; 95% CI, 1.19–2.96; p = 0.007). Restricted cubic splines suggested a linear relationship between GGT and in-hospital HF (p for nonlinearity = 0.158). The area under the curve was 0.607 (95% CI, 0.558–0.654; p = 0.007) when GGT was used to predict in-hospital HF, with a sensitivity of 57.14% and a specificity of 64.04%. Moreover, the incidence of HF significantly increased in-hospital death risk (OR, 7.75; 95% CI, 1.87–32.12; p = 0.005). Conclusions: GGT is positively associated with in-hospital HF and is an independent risk factor for in-hospital HF in STEMI patients. |
| format | Article |
| id | doaj-art-21e23889108b433a8000171d3c8ec479 |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-21e23889108b433a8000171d3c8ec4792025-01-25T10:41:19ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612500510.31083/RCM25005S1530-6550(24)01589-8Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary InterventionAn-Cheng Hou0Jian-Tong Hou1Wei-Ning Zhou2Yan-Jin Wei3Zhi-Hong Ou4Cun-Fei Liu5Department of Cardiology, Linyi People’s Hospital, Shandong Second Medical University, 276000 Linyi, Shandong, ChinaDepartment of Cardiology, Linyi People’s Hospital, Shandong Second Medical University, 276000 Linyi, Shandong, ChinaDepartment of Pathology, Linyi People’s Hospital, Shandong Second Medical University, 276000 Linyi, Shandong, ChinaDepartment of Cardiology, Linyi People’s Hospital, Shandong Second Medical University, 276000 Linyi, Shandong, ChinaDepartment of Cardiology, Linyi People’s Hospital, Shandong Second Medical University, 276000 Linyi, Shandong, ChinaDepartment of Cardiology, Linyi People’s Hospital, Shandong Second Medical University, 276000 Linyi, Shandong, ChinaBackground: To explore the association between gamma-glutamyltransferase (GGT) and in-hospital heart failure (HF) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 412 patients diagnosed with STEMI and treated with primary PCI were included in our study. Univariate and multivariate logistic regression models were used to evaluate the association between GGT and the risk of in-hospital HF in STEMI patients. The receiver operating characteristic (ROC) curve was used to assess the accuracy of GGT in predicting in-hospital HF. Results: The incidence of HF after STEMI increased significantly with increasing GGT tertiles (the first, second, and third tertile groups were 7.97%, 14.49%, and 18.38%, respectively; p = 0.039). Multivariate logistic regression analysis revealed that the risk of HF in the second and third GGT tertile groups was 2.51 times greater (95% CI, 1.06–5.96) and 2.77 times greater (95% CI, 1.13–6.81), respectively, than that in the first GGT tertile group. Each 1-unit increase in the lnGGT level was related to a 1.88-fold increased risk of HF (odds ratio, OR, 1.88; 95% CI, 1.19–2.96; p = 0.007). Restricted cubic splines suggested a linear relationship between GGT and in-hospital HF (p for nonlinearity = 0.158). The area under the curve was 0.607 (95% CI, 0.558–0.654; p = 0.007) when GGT was used to predict in-hospital HF, with a sensitivity of 57.14% and a specificity of 64.04%. Moreover, the incidence of HF significantly increased in-hospital death risk (OR, 7.75; 95% CI, 1.87–32.12; p = 0.005). Conclusions: GGT is positively associated with in-hospital HF and is an independent risk factor for in-hospital HF in STEMI patients.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25005gamma-glutamyltransferasest-segment elevation myocardial infarctionpercutaneous coronary interventionheart failure |
| spellingShingle | An-Cheng Hou Jian-Tong Hou Wei-Ning Zhou Yan-Jin Wei Zhi-Hong Ou Cun-Fei Liu Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Reviews in Cardiovascular Medicine gamma-glutamyltransferase st-segment elevation myocardial infarction percutaneous coronary intervention heart failure |
| title | Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_full | Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_fullStr | Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_full_unstemmed | Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_short | Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention |
| title_sort | association of serum gamma glutamyltransferase with in hospital heart failure in patients with st segment elevation myocardial infarction undergoing primary percutaneous coronary intervention |
| topic | gamma-glutamyltransferase st-segment elevation myocardial infarction percutaneous coronary intervention heart failure |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25005 |
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