Hepatic changes during a carrageenan induced granuloma in rats
Hepatic changes during inflammation were studied in rats bearing a carrageenan induced granuloma. In spite of a decrease in the metabolic capacity of microsomes to induce lipid peroxidation during inflammation, the endogenous lipid peroxidation remained unchanged and unrelated with the hepatic activ...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1993-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000110 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564390839189504 |
|---|---|
| author | J. Muntané Y. Fernandez S. Mitjavila M. T. Mitjavila |
| author_facet | J. Muntané Y. Fernandez S. Mitjavila M. T. Mitjavila |
| author_sort | J. Muntané |
| collection | DOAJ |
| description | Hepatic changes during inflammation were studied in rats bearing a carrageenan induced granuloma. In spite of a decrease in the metabolic capacity of microsomes to induce lipid peroxidation during inflammation, the endogenous lipid peroxidation remained unchanged and unrelated with the hepatic activities measured. The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca2+ sequestration by microsomes. |
| format | Article |
| id | doaj-art-21cf8d91a9b447b8840aa6034abbb970 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-21cf8d91a9b447b8840aa6034abbb9702025-02-03T01:11:07ZengWileyMediators of Inflammation0962-93511466-18611993-01-0121798310.1155/S0962935193000110Hepatic changes during a carrageenan induced granuloma in ratsJ. Muntané0Y. Fernandez1S. Mitjavila2M. T. Mitjavila3Unitat de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Av. Diagonal 645, Barcelona 08028, SpainInstitut de Physiologie, 2 rue F. Magendie, Toulouse 31400, FranceInstitut de Physiologie, 2 rue F. Magendie, Toulouse 31400, FranceUnitat de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Biologia, Av. Diagonal 645, Barcelona 08028, SpainHepatic changes during inflammation were studied in rats bearing a carrageenan induced granuloma. In spite of a decrease in the metabolic capacity of microsomes to induce lipid peroxidation during inflammation, the endogenous lipid peroxidation remained unchanged and unrelated with the hepatic activities measured. The continuous increase in hepatic cAMP observed during acute and chronic phases could be related to adenylate cyclase stimulation by mediators, and could be an initial step in the hepatocyte adaptation leading to the increased level of hepatic caeruloplasmin, to the reduction of cytochrome P-450 level and to the modifications of Ca2+ sequestration by microsomes.http://dx.doi.org/10.1155/S0962935193000110 |
| spellingShingle | J. Muntané Y. Fernandez S. Mitjavila M. T. Mitjavila Hepatic changes during a carrageenan induced granuloma in rats Mediators of Inflammation |
| title | Hepatic changes during a carrageenan induced granuloma in rats |
| title_full | Hepatic changes during a carrageenan induced granuloma in rats |
| title_fullStr | Hepatic changes during a carrageenan induced granuloma in rats |
| title_full_unstemmed | Hepatic changes during a carrageenan induced granuloma in rats |
| title_short | Hepatic changes during a carrageenan induced granuloma in rats |
| title_sort | hepatic changes during a carrageenan induced granuloma in rats |
| url | http://dx.doi.org/10.1155/S0962935193000110 |
| work_keys_str_mv | AT jmuntane hepaticchangesduringacarrageenaninducedgranulomainrats AT yfernandez hepaticchangesduringacarrageenaninducedgranulomainrats AT smitjavila hepaticchangesduringacarrageenaninducedgranulomainrats AT mtmitjavila hepaticchangesduringacarrageenaninducedgranulomainrats |