Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men
Objectives. The effect of the KIF6 polymorphism Trp719Arg on the risk of T2DM and T2DM with CHD remains unclear. Methods. 946 unrelated subjects of Han Chinese origin were recruited, comprising 346 controls, 312 T2DM, and 288 T2DM + CHD patients. Genotyping was performed by high-resolution melting c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/871439 |
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| _version_ | 1849307694987476992 |
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| author | Ge Wu Gui-Bin Li Bin Dai Dong-Qing Zhang |
| author_facet | Ge Wu Gui-Bin Li Bin Dai Dong-Qing Zhang |
| author_sort | Ge Wu |
| collection | DOAJ |
| description | Objectives. The effect of the KIF6 polymorphism Trp719Arg on the risk of T2DM and T2DM with CHD remains unclear. Methods. 946 unrelated subjects of Han Chinese origin were recruited, comprising 346 controls, 312 T2DM, and 288 T2DM + CHD patients. Genotyping was performed by high-resolution melting curve analysis using real-time qPCR. The impact of the variant on T2DM/T2DM + CHD and gene-sex interaction were evaluated by stepwise multiple regression analysis. Results. The frequencies of the Trp719 allele in T2DM and T2DM + CHD patients were similar to the control group, whereas significantly increased 719Arg allele frequencies were observed in male T2DM and T2DM + CHD patients compared with the corresponding control group. Further sex partition analysis revealed that only male 719Arg allele carriers had approximately 3-fold and 5-fold higher risk of T2DM and T2DM + CHD, respectively, than noncarriers. There was also a significant association between carriers and higher TG and lower HDL-C levels. Conclusion. The KIF6 719Arg allele may increase the risk of T2DM and T2DM + CHD only in Han Chinese men by modulating lipid metabolism, especially with regard to TG and HDL. |
| format | Article |
| id | doaj-art-21ce41023c4d4827a04dba523b8cd877 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-21ce41023c4d4827a04dba523b8cd8772025-08-20T03:54:42ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/871439871439Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese MenGe Wu0Gui-Bin Li1Bin Dai2Dong-Qing Zhang3Department of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, ChinaDepartment of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, ChinaDepartment of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, ChinaDepartment of Clinical Trials, The Fourth Hospital of Jilin University, Dongfeng Street No. 2643, Changchun, Jilin 130011, ChinaObjectives. The effect of the KIF6 polymorphism Trp719Arg on the risk of T2DM and T2DM with CHD remains unclear. Methods. 946 unrelated subjects of Han Chinese origin were recruited, comprising 346 controls, 312 T2DM, and 288 T2DM + CHD patients. Genotyping was performed by high-resolution melting curve analysis using real-time qPCR. The impact of the variant on T2DM/T2DM + CHD and gene-sex interaction were evaluated by stepwise multiple regression analysis. Results. The frequencies of the Trp719 allele in T2DM and T2DM + CHD patients were similar to the control group, whereas significantly increased 719Arg allele frequencies were observed in male T2DM and T2DM + CHD patients compared with the corresponding control group. Further sex partition analysis revealed that only male 719Arg allele carriers had approximately 3-fold and 5-fold higher risk of T2DM and T2DM + CHD, respectively, than noncarriers. There was also a significant association between carriers and higher TG and lower HDL-C levels. Conclusion. The KIF6 719Arg allele may increase the risk of T2DM and T2DM + CHD only in Han Chinese men by modulating lipid metabolism, especially with regard to TG and HDL.http://dx.doi.org/10.1155/2014/871439 |
| spellingShingle | Ge Wu Gui-Bin Li Bin Dai Dong-Qing Zhang Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men Journal of Diabetes Research |
| title | Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men |
| title_full | Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men |
| title_fullStr | Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men |
| title_full_unstemmed | Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men |
| title_short | Novel KIF6 Polymorphism Increases Susceptibility to Type 2 Diabetes Mellitus and Coronary Heart Disease in Han Chinese Men |
| title_sort | novel kif6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in han chinese men |
| url | http://dx.doi.org/10.1155/2014/871439 |
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