The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP
Purpose. To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP). Methods. The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The c...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/19469 |
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| _version_ | 1832554892858753024 |
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| author | Zhang Xiping Tian Hua Chen Hanqing Chen Li Wang Zhiwei Wang Keyi Yan Wei Li Yun Li Qingyu He Qing Wang Fei |
| author_facet | Zhang Xiping Tian Hua Chen Hanqing Chen Li Wang Zhiwei Wang Keyi Yan Wei Li Yun Li Qingyu He Qing Wang Fei |
| author_sort | Zhang Xiping |
| collection | DOAJ |
| description | Purpose. To observe the protecting effects and mechanisms
of Baicalin and Octreotide on heart injury in rats with severe
acute pancreatitis (SAP).
Methods. The SAP rat models were randomly divided into
the model group, Baicalin-treated group, Octreotide treated group,
and sham operation group. The contents of some inflammatory
indexes in blood were determined. The rat mortality, pathological
changes of heart, the changes of NF-κB,
P-Selectin, Bax, Bcl-2, and Caspase-3 protein
expression levels as well as apoptotic index were observed in all
groups, respectively, at 3 hours, 6 hours, and 12 hours after
operation.
Results. The survival rate of model group was less
than treated groups at 12 hours, difference was significant. The
contents of some inflammatory indexes of the treated groups were
lower than those of the model group to various degrees at
different time points. The pathological myocardial changes under
light microscope were milder in treated groups than in model
group. The changes of
NF-κB,
P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in
all groups were different. There was only a case of myocardial
cell apoptosis in an Octreotide-treated group at 6 hours.
Conclusion. Baicalin and Octreotide have protecting
effects on heart injury of rats with SAP. |
| format | Article |
| id | doaj-art-21cdf11c2a94402a874ebce4b1187a83 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-21cdf11c2a94402a874ebce4b1187a832025-02-03T05:50:13ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/1946919469The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAPZhang Xiping0Tian Hua1Chen Hanqing2Chen Li3Wang Zhiwei4Wang Keyi5Yan Wei6Li Yun7Li Qingyu8He Qing9Wang Fei10Department of General Surgery, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaDepartment of General Surgery, Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang Province 310009, ChinaZhejiang University of Traditional Chinese Medical, Hangzhou, Zhejiang Province 310053, ChinaDepartment of General Surgery, Second Affiliated Hospital of Zhejiang, University School of Medicine, Hangzhou, Zhejiang Province 310009, ChinaCentralab, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaCentralab, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaManufacturing Laboratory, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaManufacturing Laboratory, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaManufacturing Laboratory, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaManufacturing Laboratory, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaManufacturing Laboratory, Hangzhou First People’s Hospital, Hangzhou, Zhejiang Province 310006, ChinaPurpose. To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP). Methods. The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The contents of some inflammatory indexes in blood were determined. The rat mortality, pathological changes of heart, the changes of NF-κB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels as well as apoptotic index were observed in all groups, respectively, at 3 hours, 6 hours, and 12 hours after operation. Results. The survival rate of model group was less than treated groups at 12 hours, difference was significant. The contents of some inflammatory indexes of the treated groups were lower than those of the model group to various degrees at different time points. The pathological myocardial changes under light microscope were milder in treated groups than in model group. The changes of NF-κB, P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in all groups were different. There was only a case of myocardial cell apoptosis in an Octreotide-treated group at 6 hours. Conclusion. Baicalin and Octreotide have protecting effects on heart injury of rats with SAP.http://dx.doi.org/10.1155/2007/19469 |
| spellingShingle | Zhang Xiping Tian Hua Chen Hanqing Chen Li Wang Zhiwei Wang Keyi Yan Wei Li Yun Li Qingyu He Qing Wang Fei The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP Mediators of Inflammation |
| title | The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP |
| title_full | The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP |
| title_fullStr | The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP |
| title_full_unstemmed | The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP |
| title_short | The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP |
| title_sort | protecting effects and mechanisms of baicalin and octreotide on heart injury in rats with sap |
| url | http://dx.doi.org/10.1155/2007/19469 |
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