The Protecting Effects and Mechanisms of Baicalin and Octreotide on Heart Injury in Rats with SAP
Purpose. To observe the protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with severe acute pancreatitis (SAP). Methods. The SAP rat models were randomly divided into the model group, Baicalin-treated group, Octreotide treated group, and sham operation group. The c...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/19469 |
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| Summary: | Purpose. To observe the protecting effects and mechanisms
of Baicalin and Octreotide on heart injury in rats with severe
acute pancreatitis (SAP).
Methods. The SAP rat models were randomly divided into
the model group, Baicalin-treated group, Octreotide treated group,
and sham operation group. The contents of some inflammatory
indexes in blood were determined. The rat mortality, pathological
changes of heart, the changes of NF-κB,
P-Selectin, Bax, Bcl-2, and Caspase-3 protein
expression levels as well as apoptotic index were observed in all
groups, respectively, at 3 hours, 6 hours, and 12 hours after
operation.
Results. The survival rate of model group was less
than treated groups at 12 hours, difference was significant. The
contents of some inflammatory indexes of the treated groups were
lower than those of the model group to various degrees at
different time points. The pathological myocardial changes under
light microscope were milder in treated groups than in model
group. The changes of
NF-κB,
P-Selectin, Bax, Bcl-2, and Caspase-3 protein expression levels in
all groups were different. There was only a case of myocardial
cell apoptosis in an Octreotide-treated group at 6 hours.
Conclusion. Baicalin and Octreotide have protecting
effects on heart injury of rats with SAP. |
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| ISSN: | 0962-9351 1466-1861 |