QRICH1, as a key effector of endoplasmic reticulum stress, enhances HBV in promoting HMGB1 translocation and secretion in hepatocytes

QRICH1, as a key effector of endoplasmic reticulum stress, enhances HBV in promoting HMGB1 translocation and secretion in hepatocytes

Background: Extracellular high mobility group box 1 (HMGB1) serves as a damage-associated molecular pattern (DAMP) and leads to diverse biological effects, including the aggravation of HBV-related liver diseases. However, mechanisms underlying HMGB1 secretion in HBV-induced hepatic injury and fibros...

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Bibliographic Details
Main Authors: Ying Feng, Yucai Geng, Zhixiang Liu, Lin Lu, Chen Cai, Chenke Ding, Shuyu Dong, Bo Gao
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Immunobiology
Subjects:
QRICH1
Endoplasmic reticulum stress
HMGB1
SIRT6
HBV
Hepatic fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0171298525000476
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