Lead-induced hypertension and cognitive dysfunction: brain amyloid pathology

Lead-induced hypertension and cognitive dysfunction: brain amyloid pathology

Abstract Background Lead (Pb) exposure is a recognized environmental risk factor for cognitive decline and may aggravate Alzheimer's disease (AD) pathology through hypertension-related mechanisms. However, the specific role of mineralocorticoid receptor (MR) signaling in this process remains un...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yunbo Zhang, Yao Xu, Yanling Song, Yachun Wang, Minghui Chen, Xinbo Ji, Yunyun Lin, Shenhong Gu
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	European Journal of Medical Research
Subjects:	Alzheimer’s disease Pb Cognitive impairment Neuroinflammation Amyloid plaque Amlodipine
Online Access:	https://doi.org/10.1186/s40001-025-02965-x
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

CD22 modulation alleviates amyloid β-induced neuroinflammation
by: Yu Dong Mai, et al.
Published: (2025-02-01)

Amyloid-β Inhibiting Peptides: An Innovative Strategy for Alzheimer’s Disease Treatment
by: Sajjad Molavipordanjani, et al.
Published: (2023-11-01)

The effect of oral administration of NXP032 equivalent to intraperitoneal administration in an Alzheimer’s disease model
by: Jae Min Lee, et al.
Published: (2025-07-01)

Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
by: Dilpreet Kour, et al.
Published: (2025-03-01)

Gentiacaulein inhibits glucose transport to induce PRKAA1-mediated autophagy to clear amyloid beta and associated inflammation in primary astrocytes
by: Ankita Sharma, et al.
Published: (2024-12-01)

Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes
by: Johannes de Munter, et al.
Published: (2025-07-01)

Implications of Mucin-Type <i>O</i>-Glycosylation in Alzheimer’s Disease
by: Nancy Vela Navarro, et al.
Published: (2025-04-01)

Passive Anti-amyloid Beta Monoclonal Antibodies: Lessons Learned over Past 20 Years
by: Alexandra Wicker, et al.
Published: (2024-10-01)

Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer’s Disease Therapeutics
by: Daniela Dias, et al.
Published: (2025-01-01)

The role of neuroinflammation in cerebral amyloid angiopathy
by: Hilde van den Brink, et al.
Published: (2024-12-01)

Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
by: Niklas Mattsson‐Carlgren, et al.
Published: (2021-05-01)

Anti-amyloid Monoclonal Antibodies for Alzheimer’s Disease: A New Hope? (Review)
by: I. A. Mazerkina
Published: (2025-04-01)

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression
by: Cong He, et al.
Published: (2025-03-01)

Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC
by: Kristian S. Frederiksen, et al.
Published: (2025-05-01)

Plasma amyloid‐β oligomerization tendency as a potential predictor for conversion from mild cognitive impairment to Alzheimer's dementia: Findings from the GMCII cohort
by: Yuhan Xie, et al.
Published: (2025-01-01)

Physiopathological mechanisms underlying Alzheimer’s disease: a narrative review
by: Eliasz Engelhardt, et al.
Published: (2024-12-01)

Experiences from Clinical Research and Routine Use of Florbetaben Amyloid PET—A Decade of Post-Authorization Insights
by: Aleksandar Jovalekic, et al.
Published: (2024-12-01)

Faster decline of very prodromal dementia with Lewy bodies when amyloid positive
by: Frédéric Blanc, et al.
Published: (2025-04-01)

Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: A meta-analysis
by: Fatemeh Sedghi, et al.
Published: (2025-12-01)

Molecular Mechanisms of Alzheimer’s Disease Induced by Amyloid-β and Tau Phosphorylation Along with RhoA Activity: Perspective of RhoA/Rho-Associated Protein Kinase Inhibitors for Neuronal Therapy
by: Eun Hee Ahn, et al.
Published: (2025-01-01)

Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults with β-amyloid deposition
by: Jenna K. Blujus, et al.
Published: (2025-06-01)

Interplay Between Aging and Tau Pathology in Alzheimer’s Disease: Mechanisms and Translational Perspectives
by: Mohammed Alrouji, et al.
Published: (2025-06-01)

Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer’s Disease Model
by: Kunie Ando, et al.
Published: (2025-01-01)

Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology
by: Printha Wijesinghe, et al.
Published: (2024-12-01)

Compensatory enhancement of orexinergic system functionality induced by amyloid-β protein: a neuroprotective response in Alzheimer’s disease
by: Chenyu Zhuang, et al.
Published: (2025-03-01)

Head to head comparison of two PET/CT imaging agents, [18F]D3FSP ([18F]P16-129) and [18F]AV45, in patients with alzheimer’s disease
by: David Alexoff, et al.
Published: (2025-06-01)

Comparison of plasma ALZpath p-Tau217 with Lilly p-Tau217 and p-Tau181 in a neuropathological cohort
by: Divya Bali, et al.
Published: (2025-06-01)

The evolution of Alzheimer’s disease therapies: A comprehensive review
by: Pritama Paul, et al.
Published: (2024-01-01)

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain
by: Evgenia Salta, et al.
Published: (2016-08-01)

Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease
by: Chensi Liang, et al.
Published: (2025-03-01)

The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease
by: Rayees Ahmad Naik, et al.
Published: (2025-02-01)

The Efficacy of Anti-amyloid Monoclonal Antibodies in Early Alzheimer’s Dementia: A Systematic Review
by: Alyaa Mostafa, et al.
Published: (2025-05-01)

Cortical Diffusivity, a Biomarker for Early Neuronal Damage, Is Associated with Amyloid-β Deposition: A Pilot Study
by: Justine Debatisse, et al.
Published: (2025-01-01)

Central Insulin-like Growth Factor-1 Treatment Enhances Working and Reference Memory by Reducing Neuroinflammation and Amyloid Beta Deposition in a Rat Model of Sporadic Alzheimer’s Disease
by: Joanna Dunacka, et al.
Published: (2025-04-01)

Efficacy of Ginkgo biloba extract in amyloid PET-positive patients with mild cognitive impairment
by: YoungSoon Yang, et al.
Published: (2025-08-01)

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease
by: Yunhua Zhang, et al.
Published: (2025-05-01)

Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer’s disease in the cortex of APP/PS1 mice
by: Giorgia Sarti, et al.
Published: (2025-05-01)

A Review Article on Oxidative Stress Markers F2-Isoprostanes and Presenilin-1 in Alzheimer’s Disease
by: Dilip Raj Timalsina, et al.
Published: (2025-05-01)

Alzheimer’s Disease in the Age of Precision Medicine: Advances in Pathophysiology, Clinical Management and Therapeutic Strategies
by: Michał Piotrowski, et al.
Published: (2025-04-01)

Perspective: Minimally clinically important “symptomatic” benefit associated with disease modification resulting from anti‐amyloid immunotherapy
by: John Alam, et al.
Published: (2025-01-01)