mPEG-PCL Nanoparticles to Improve Oral Bioavailability of Acalabrutinib: Effect of Polymer Lipophilicity and Hydrophilicity on Physicochemical Properties and In Vivo Performance in Rats

mPEG-PCL Nanoparticles to Improve Oral Bioavailability of Acalabrutinib: Effect of Polymer Lipophilicity and Hydrophilicity on Physicochemical Properties and In Vivo Performance in Rats

<b>Background/Objectives:</b> This research focuses on the development and optimization of polymer–lipid hybrid nanoparticles (PLHNs) using two grades of mPEG-PCL co-polymers in combination with DPPC and lecithin to address the biopharmaceutical challenges of acalabrutinib (ACP), a selec...

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Bibliographic Details
Main Authors: Swagata Sinha, Punna Rao Ravi, Sahadevan Rajesh Rashmi, Łukasz Szeleszczuk
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
co-polymerization
amphiphilic co-polymer
central composite design
nanoparticles
oral pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/17/6/774
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