Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases
Background: Considering the cardiovascular complications in Type 2 Diabetes Mellitus (T2DM) despite normal Total Cholesterol (TC) and Low Density Lipoprotein (LDL) levels, Non High Density Lipoprotein (non-HDL-C) and Apolipoprotein B (ApoB) were added as secondary targets and have been increasingly...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2024-07-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
| Subjects: | |
| Online Access: | https://www.jkimsu.com/jkimsu-vol13no3/JKIMSU,%20Vol.%2013,%20No.%203,%20July-September%202024%20Page%20146-154.pdf |
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| Summary: | Background: Considering the cardiovascular complications in Type 2 Diabetes Mellitus (T2DM) despite normal Total Cholesterol (TC) and Low Density Lipoprotein (LDL) levels, Non High Density Lipoprotein (non-HDL-C) and
Apolipoprotein B (ApoB) were added as secondary targets and have been increasingly acknowledged as measures of risk estimation for developing atherosclerotic Cardiovascular Disease (CVD). Aim and Objectives: To study the
correlation between ApoB100 and non-HDL-C in assessing the risk of cardiovascular complications in T2DM patients. Material and Methods: A total of 90 T2DM patients attending Medicine and Cardiology outpatient departments were recruited for the study. They were categorised into 2 groups -T2DM with CVD and T2DM without CVD. Three ml of fasting venous blood sample was taken from each patient and fasting blood sugar, TC, triglycerides, HDL-C and ApoB were estimated on VITROS 5600 Integrated Autoanalyser. LDL-C was calculated using Friedewald formula and non-HDL-C was calculated by subtracting HDL-C from TC. Results: The levels of ApoB and non-HDL-C in T2DM patients with CVD and without CVD were found to be significant with p < 0.001. There was a significant
correlation between ApoB and non-HDL-C values in both the groups as analysed by Karl Pearson's correlation coefficient(p <0.001). After linear regression analysis, non-HDL-C was found to have a strong correlation with ApoB100 in both the groups with r of 0.753 and 0.215 respectively (p < 0.001). Conclusion: The present study has demonstrated a strong correlation between ApoB and non-HDL-C in T2DM patients with or without CVD and hence can substitute for each other. |
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| ISSN: | 2231-4261 |