Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection
Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection...
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| Format: | Article |
| Language: | English |
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Sciendo
2014-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2014-0027 |
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| author | Shen Jie Yang Kai Sun Caihua Zheng Minxia |
| author_facet | Shen Jie Yang Kai Sun Caihua Zheng Minxia |
| author_sort | Shen Jie |
| collection | DOAJ |
| description | Correlation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI). HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, protocatechuic acid and their metabolites in rat serum may contribute to the efficacy of SMI. Assessment of antioxidant properties indicated that differences in the composition of serum powder of SMI caused differences in vascular endothelial cell protection. When bivariate correlation was carried out it was found that salvianolic acid B, tanshinol and protocatechuic aldehyde were active components of SMI because they were correlated to antioxidant properties. |
| format | Article |
| id | doaj-art-21a29b7d26ed48bb9f179eb81031871d |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-21a29b7d26ed48bb9f179eb81031871d2025-02-02T23:02:22ZengSciendoActa Pharmaceutica1846-95582014-09-0164332533410.2478/acph-2014-0027acph-2014-0027Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell ProtectionShen Jie0Yang Kai1Sun Caihua2Zheng Minxia3The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou Zhejiang Province – 310 006, ChinaThe First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou Zhejiang Province – 310 003, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou Zhejiang Province – 310 006, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou Zhejiang Province – 310 006, ChinaCorrelation analysis based on chromatograms and pharmacological activities is essential for understanding the effective components in complex herbal medicines. In this report, HPLC and measurement of antioxidant properties were used to describe the active ingredients of Salvia miltiorrhiza injection (SMI). HPLC results showed that tanshinol, protocatechuic aldehyde, rosmarinic acid, salvianolic acid B, protocatechuic acid and their metabolites in rat serum may contribute to the efficacy of SMI. Assessment of antioxidant properties indicated that differences in the composition of serum powder of SMI caused differences in vascular endothelial cell protection. When bivariate correlation was carried out it was found that salvianolic acid B, tanshinol and protocatechuic aldehyde were active components of SMI because they were correlated to antioxidant properties.https://doi.org/10.2478/acph-2014-0027salvia miltiorrhiza injectionhplcantioxidant activitycorrelation analysissalvianolic acid |
| spellingShingle | Shen Jie Yang Kai Sun Caihua Zheng Minxia Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection Acta Pharmaceutica salvia miltiorrhiza injection hplc antioxidant activity correlation analysis salvianolic acid |
| title | Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection |
| title_full | Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection |
| title_fullStr | Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection |
| title_full_unstemmed | Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection |
| title_short | Analysis of Active Components in Salvia Miltiorrhiza Injection Based on Vascular Endothelial Cell Protection |
| title_sort | analysis of active components in salvia miltiorrhiza injection based on vascular endothelial cell protection |
| topic | salvia miltiorrhiza injection hplc antioxidant activity correlation analysis salvianolic acid |
| url | https://doi.org/10.2478/acph-2014-0027 |
| work_keys_str_mv | AT shenjie analysisofactivecomponentsinsalviamiltiorrhizainjectionbasedonvascularendothelialcellprotection AT yangkai analysisofactivecomponentsinsalviamiltiorrhizainjectionbasedonvascularendothelialcellprotection AT suncaihua analysisofactivecomponentsinsalviamiltiorrhizainjectionbasedonvascularendothelialcellprotection AT zhengminxia analysisofactivecomponentsinsalviamiltiorrhizainjectionbasedonvascularendothelialcellprotection |