Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma
We describe the case of a 13-year-old boy who presented with persistent thrombocytopenia during maintenance chemotherapy with mercaptopurine and methotrexate for T cell lymphoblastic lymphoma. He was diagnosed with immune thrombocytopenia (ITP) after thorough investigations for the relapse of lympho...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/2897325 |
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| _version_ | 1832547488870957056 |
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| author | Kayo Tokeji Sachi Sakaguchi Tomoko Kurimoto Junya Fujimura Toshiaki Shimizu |
| author_facet | Kayo Tokeji Sachi Sakaguchi Tomoko Kurimoto Junya Fujimura Toshiaki Shimizu |
| author_sort | Kayo Tokeji |
| collection | DOAJ |
| description | We describe the case of a 13-year-old boy who presented with persistent thrombocytopenia during maintenance chemotherapy with mercaptopurine and methotrexate for T cell lymphoblastic lymphoma. He was diagnosed with immune thrombocytopenia (ITP) after thorough investigations for the relapse of lymphoma and was successfully treated with immunoglobulin and steroids. ITP is known to be associated with chronic lymphocytic leukemia, Hodgkin lymphoma, and various types of non-Hodgkin lymphoma but rarely with T cell non-Hodgkin lymphoma or in children. Diagnosis of ITP with lymphoma is challenging due to the many factors affecting platelet counts, and ITP often complicates the diagnosis or treatment course of lymphoma. The underlying mechanism of ITP with NHL is still unclear. Drug-induced immunomodulation with a reduction of regulatory T cells might have contributed to the development of ITP in our case. |
| format | Article |
| id | doaj-art-219d4030234b45df8204b063564c37a0 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-219d4030234b45df8204b063564c37a02025-02-03T06:44:37ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/28973252897325Immune Thrombocytopenia in a Child with T Cell Lymphoblastic LymphomaKayo Tokeji0Sachi Sakaguchi1Tomoko Kurimoto2Junya Fujimura3Toshiaki Shimizu4Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, JapanDepartment of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, JapanDepartment of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, JapanDepartment of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, JapanDepartment of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, JapanWe describe the case of a 13-year-old boy who presented with persistent thrombocytopenia during maintenance chemotherapy with mercaptopurine and methotrexate for T cell lymphoblastic lymphoma. He was diagnosed with immune thrombocytopenia (ITP) after thorough investigations for the relapse of lymphoma and was successfully treated with immunoglobulin and steroids. ITP is known to be associated with chronic lymphocytic leukemia, Hodgkin lymphoma, and various types of non-Hodgkin lymphoma but rarely with T cell non-Hodgkin lymphoma or in children. Diagnosis of ITP with lymphoma is challenging due to the many factors affecting platelet counts, and ITP often complicates the diagnosis or treatment course of lymphoma. The underlying mechanism of ITP with NHL is still unclear. Drug-induced immunomodulation with a reduction of regulatory T cells might have contributed to the development of ITP in our case.http://dx.doi.org/10.1155/2016/2897325 |
| spellingShingle | Kayo Tokeji Sachi Sakaguchi Tomoko Kurimoto Junya Fujimura Toshiaki Shimizu Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma Case Reports in Hematology |
| title | Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma |
| title_full | Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma |
| title_fullStr | Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma |
| title_full_unstemmed | Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma |
| title_short | Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma |
| title_sort | immune thrombocytopenia in a child with t cell lymphoblastic lymphoma |
| url | http://dx.doi.org/10.1155/2016/2897325 |
| work_keys_str_mv | AT kayotokeji immunethrombocytopeniainachildwithtcelllymphoblasticlymphoma AT sachisakaguchi immunethrombocytopeniainachildwithtcelllymphoblasticlymphoma AT tomokokurimoto immunethrombocytopeniainachildwithtcelllymphoblasticlymphoma AT junyafujimura immunethrombocytopeniainachildwithtcelllymphoblasticlymphoma AT toshiakishimizu immunethrombocytopeniainachildwithtcelllymphoblasticlymphoma |