Design of therapeutic siRNAs for potential application to infection with chikungunya virus
Emergence of the Chikungunya virus (CHIKV) is a new threat in the world. The disastrous effect of this virus and the unavailability of specific drugs complicated the control and management of the disease. The development of a siRNA-based drug using multiple computational tools could be a way out as...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402500204X |
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| _version_ | 1832573130408722432 |
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| author | Ahmed Ahsan Adib Muhammad Manjurul Karim |
| author_facet | Ahmed Ahsan Adib Muhammad Manjurul Karim |
| author_sort | Ahmed Ahsan Adib |
| collection | DOAJ |
| description | Emergence of the Chikungunya virus (CHIKV) is a new threat in the world. The disastrous effect of this virus and the unavailability of specific drugs complicated the control and management of the disease. The development of a siRNA-based drug using multiple computational tools could be a way out as one of its therapeutics. Currently, very few siRNAs against CHIKV have been computationally designed and published. Here, we considered various parts of the CHIKV genome encoding different essential protein-coding genes for designing siRNAs with a view to silencing them, thereby rendering the virus inactive. Seven potential primary siRNAs were constructed, of which, five are hereafter recommended to be used as a therapeutic tool against the virus. |
| format | Article |
| id | doaj-art-219be95c734c4f8fa30dab94fc87703a |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-219be95c734c4f8fa30dab94fc87703a2025-02-02T05:28:18ZengElsevierHeliyon2405-84402025-01-01112e41824Design of therapeutic siRNAs for potential application to infection with chikungunya virusAhmed Ahsan Adib0Muhammad Manjurul Karim1Department of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshCorresponding author.; Department of Microbiology, University of Dhaka, Dhaka, 1000, BangladeshEmergence of the Chikungunya virus (CHIKV) is a new threat in the world. The disastrous effect of this virus and the unavailability of specific drugs complicated the control and management of the disease. The development of a siRNA-based drug using multiple computational tools could be a way out as one of its therapeutics. Currently, very few siRNAs against CHIKV have been computationally designed and published. Here, we considered various parts of the CHIKV genome encoding different essential protein-coding genes for designing siRNAs with a view to silencing them, thereby rendering the virus inactive. Seven potential primary siRNAs were constructed, of which, five are hereafter recommended to be used as a therapeutic tool against the virus.http://www.sciencedirect.com/science/article/pii/S240584402500204XChikungunyaRNA interferenceGene silencingTherapeutics |
| spellingShingle | Ahmed Ahsan Adib Muhammad Manjurul Karim Design of therapeutic siRNAs for potential application to infection with chikungunya virus Heliyon Chikungunya RNA interference Gene silencing Therapeutics |
| title | Design of therapeutic siRNAs for potential application to infection with chikungunya virus |
| title_full | Design of therapeutic siRNAs for potential application to infection with chikungunya virus |
| title_fullStr | Design of therapeutic siRNAs for potential application to infection with chikungunya virus |
| title_full_unstemmed | Design of therapeutic siRNAs for potential application to infection with chikungunya virus |
| title_short | Design of therapeutic siRNAs for potential application to infection with chikungunya virus |
| title_sort | design of therapeutic sirnas for potential application to infection with chikungunya virus |
| topic | Chikungunya RNA interference Gene silencing Therapeutics |
| url | http://www.sciencedirect.com/science/article/pii/S240584402500204X |
| work_keys_str_mv | AT ahmedahsanadib designoftherapeuticsirnasforpotentialapplicationtoinfectionwithchikungunyavirus AT muhammadmanjurulkarim designoftherapeuticsirnasforpotentialapplicationtoinfectionwithchikungunyavirus |