The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem Cells
Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. Various preclinic...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/261697 |
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| _version_ | 1832553174279389184 |
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| author | Tao Du Ying-Jian Zhu |
| author_facet | Tao Du Ying-Jian Zhu |
| author_sort | Tao Du |
| collection | DOAJ |
| description | Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. Various preclinical studies indicated the beneficial effects of MSCs in alleviating renal injury and accelerating tissue repair. However the mechanisms responsible for these effects are incompletely understood. In the recent years, anti-inflammatory/immunoregulatory properties of MSCs have become one of the important issues in the treatment of AKI. This review will summarize the current literature on the regulation of inflammatory mediators via exogenous MSCs contributing to the recovery from AKI. |
| format | Article |
| id | doaj-art-2198c8f009694650af09476922a28943 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2198c8f009694650af09476922a289432025-02-03T05:55:19ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/261697261697The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem CellsTao Du0Ying-Jian Zhu1Department of Urology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, ChinaDepartment of Urology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, ChinaAcute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity. Inflammation is believed to play a major role in the pathophysiology of AKI. Exogenous mesenchymal stem cells (MSCs) are now under extensive investigation as a potential therapy for AKI. Various preclinical studies indicated the beneficial effects of MSCs in alleviating renal injury and accelerating tissue repair. However the mechanisms responsible for these effects are incompletely understood. In the recent years, anti-inflammatory/immunoregulatory properties of MSCs have become one of the important issues in the treatment of AKI. This review will summarize the current literature on the regulation of inflammatory mediators via exogenous MSCs contributing to the recovery from AKI.http://dx.doi.org/10.1155/2014/261697 |
| spellingShingle | Tao Du Ying-Jian Zhu The Regulation of Inflammatory Mediators in Acute Kidney Injury via Exogenous Mesenchymal Stem Cells Mediators of Inflammation |
| title | The Regulation of Inflammatory Mediators in Acute Kidney
Injury via Exogenous Mesenchymal Stem Cells |
| title_full | The Regulation of Inflammatory Mediators in Acute Kidney
Injury via Exogenous Mesenchymal Stem Cells |
| title_fullStr | The Regulation of Inflammatory Mediators in Acute Kidney
Injury via Exogenous Mesenchymal Stem Cells |
| title_full_unstemmed | The Regulation of Inflammatory Mediators in Acute Kidney
Injury via Exogenous Mesenchymal Stem Cells |
| title_short | The Regulation of Inflammatory Mediators in Acute Kidney
Injury via Exogenous Mesenchymal Stem Cells |
| title_sort | regulation of inflammatory mediators in acute kidney injury via exogenous mesenchymal stem cells |
| url | http://dx.doi.org/10.1155/2014/261697 |
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