Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis
Abstract Background Patients on long-term dialysis for end-stage kidney disease have a high mortality rate, predominantly due to sudden cardiac death (SCD), which is associated with an increased risk of arrhythmias compared to the general population. Thus, the current systematic review and meta-anal...
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2025-01-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | https://doi.org/10.1186/s43044-025-00606-6 |
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| author | Subhash Chander Ahmad Bin Aamir Rabia Latif Om Parkash F. N. U. Sorath Sam Tan Abhi Chand Lohana Sheena Shiwlani Mohammed Yaqub Nadeem |
| author_facet | Subhash Chander Ahmad Bin Aamir Rabia Latif Om Parkash F. N. U. Sorath Sam Tan Abhi Chand Lohana Sheena Shiwlani Mohammed Yaqub Nadeem |
| author_sort | Subhash Chander |
| collection | DOAJ |
| description | Abstract Background Patients on long-term dialysis for end-stage kidney disease have a high mortality rate, predominantly due to sudden cardiac death (SCD), which is associated with an increased risk of arrhythmias compared to the general population. Thus, the current systematic review and meta-analysis aimed to investigate the incidence of SCD among dialysis patients at risk of arrhythmia. Methods This systematic review and meta-analysis followed the PRISMA guidelines. PubMed, Cochrane Library, Google Scholar, Medline, and Europe PMC were searched for articles meeting our inclusion criteria. Studies with risk assessment of arrhythmias and the incidence of SCD in dialysis patients were considered for inclusion. Effect size from eligible studies was pooled using a random effects model and restricted maximum likelihood estimation. Heterogeneity was quantified using the I 2 statistic, and the risk of publication bias was evaluated by visually inspecting funnel plots. Results Our search strategy yielded 5861 studies, of which 1960 duplicate entries were removed in the prescreening stage, 3326 were excluded after title/abstract screening, and 519 after full-text screening for not meeting our inclusion criteria. Finally, 11 studies were included in the analysis, and two more were selected from the bibliography list of previous reviews. Eight included studies were randomized controlled trials, and five were cohort studies, which provided a pooled population size of 12,611 dialysis patients for the meta-analysis, which indicated a significantly larger effect size of arrhythmia [Cohen’s d = 110.38 (95%CI 42.72–178.05), p = 0.0]. Visual assessment of the funnel plot indicated no publication bias. Conclusion SCD remains a significant public health concern, particularly in patients undergoing dialysis. Meta-analysis results show that bradyarrhythmia is a common arrhythmic condition leading to SCD; however, other arrhythmias should also be considered. |
| format | Article |
| id | doaj-art-21884e42ac554aa7946c490b551bccbd |
| institution | Kabale University |
| issn | 2090-911X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj-art-21884e42ac554aa7946c490b551bccbd2025-01-19T12:28:22ZengSpringerOpenThe Egyptian Heart Journal2090-911X2025-01-0177111110.1186/s43044-025-00606-6Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysisSubhash Chander0Ahmad Bin Aamir1Rabia Latif2Om Parkash3F. N. U. Sorath4Sam Tan5Abhi Chand Lohana6Sheena Shiwlani7Mohammed Yaqub Nadeem8Department of Critical Care Medicine, Mayo ClinicDepartment of Medicine, Faisalabad Medical UniversityDepartment of Physiology, College of Medicine, Imam Abdulrahman, Bin Faisal UniversityDepartment of Medicine, Montefiore Medical CenterDepartment of Anesthesiology, Dow Health ScienceDepartment of Medicine, Icahn School of MedicineDepartment of Medicine, Western Michigan UniversityDepartment of Medicine, Icahn School of MedicineDepartment of Medicine, Western Michigan UniversityAbstract Background Patients on long-term dialysis for end-stage kidney disease have a high mortality rate, predominantly due to sudden cardiac death (SCD), which is associated with an increased risk of arrhythmias compared to the general population. Thus, the current systematic review and meta-analysis aimed to investigate the incidence of SCD among dialysis patients at risk of arrhythmia. Methods This systematic review and meta-analysis followed the PRISMA guidelines. PubMed, Cochrane Library, Google Scholar, Medline, and Europe PMC were searched for articles meeting our inclusion criteria. Studies with risk assessment of arrhythmias and the incidence of SCD in dialysis patients were considered for inclusion. Effect size from eligible studies was pooled using a random effects model and restricted maximum likelihood estimation. Heterogeneity was quantified using the I 2 statistic, and the risk of publication bias was evaluated by visually inspecting funnel plots. Results Our search strategy yielded 5861 studies, of which 1960 duplicate entries were removed in the prescreening stage, 3326 were excluded after title/abstract screening, and 519 after full-text screening for not meeting our inclusion criteria. Finally, 11 studies were included in the analysis, and two more were selected from the bibliography list of previous reviews. Eight included studies were randomized controlled trials, and five were cohort studies, which provided a pooled population size of 12,611 dialysis patients for the meta-analysis, which indicated a significantly larger effect size of arrhythmia [Cohen’s d = 110.38 (95%CI 42.72–178.05), p = 0.0]. Visual assessment of the funnel plot indicated no publication bias. Conclusion SCD remains a significant public health concern, particularly in patients undergoing dialysis. Meta-analysis results show that bradyarrhythmia is a common arrhythmic condition leading to SCD; however, other arrhythmias should also be considered.https://doi.org/10.1186/s43044-025-00606-6Sudden cardiac deathArrhythmiaBradyarrhythmiaESRDHemodialysis |
| spellingShingle | Subhash Chander Ahmad Bin Aamir Rabia Latif Om Parkash F. N. U. Sorath Sam Tan Abhi Chand Lohana Sheena Shiwlani Mohammed Yaqub Nadeem Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis The Egyptian Heart Journal Sudden cardiac death Arrhythmia Bradyarrhythmia ESRD Hemodialysis |
| title | Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis |
| title_full | Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis |
| title_fullStr | Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis |
| title_full_unstemmed | Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis |
| title_short | Type of arrhythmias and the risk of sudden cardiac death in dialysis patients: a systematic review and meta-analysis |
| title_sort | type of arrhythmias and the risk of sudden cardiac death in dialysis patients a systematic review and meta analysis |
| topic | Sudden cardiac death Arrhythmia Bradyarrhythmia ESRD Hemodialysis |
| url | https://doi.org/10.1186/s43044-025-00606-6 |
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