Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1
In the present research work, the levels of protein biomarkers specific to diabetes mellitus type 2 in the Pakistani population using proteomic technology have been identified and characterized and effect of high dose thiamine has been seen on the levels of these marker proteins. Diabetic patients a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/150176 |
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| _version_ | 1832565010999541760 |
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| author | Samreen Riaz |
| author_facet | Samreen Riaz |
| author_sort | Samreen Riaz |
| collection | DOAJ |
| description | In the present research work, the levels of protein biomarkers specific to diabetes mellitus type 2 in the Pakistani population using proteomic technology have been identified and characterized and effect of high dose thiamine has been seen on the levels of these marker proteins. Diabetic patients and normal healthy controls were recruited from the Sheikh Zayed Hospital, Lahore, Pakistan. Total biochemical assays and proteins were estimated by modern proteomic techniques. Some proteins were up- and downregulated in diabetic samples as compared to control and decreased after thiamine therapy, while other protein markers did not show a significant change after the thiamine therapy. The effect of high dose thiamine on the levels of these identified protein biomarkers in the human urine has also been observed. Assessment of the levels of these biomarkers will be helpful in not only early diagnosis but also prognosis of diabetes mellitus type 2. |
| format | Article |
| id | doaj-art-2168fc8b96c444c2a6985493c460d9fc |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2168fc8b96c444c2a6985493c460d9fc2025-02-03T01:09:33ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/150176150176Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1Samreen Riaz0Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, PakistanIn the present research work, the levels of protein biomarkers specific to diabetes mellitus type 2 in the Pakistani population using proteomic technology have been identified and characterized and effect of high dose thiamine has been seen on the levels of these marker proteins. Diabetic patients and normal healthy controls were recruited from the Sheikh Zayed Hospital, Lahore, Pakistan. Total biochemical assays and proteins were estimated by modern proteomic techniques. Some proteins were up- and downregulated in diabetic samples as compared to control and decreased after thiamine therapy, while other protein markers did not show a significant change after the thiamine therapy. The effect of high dose thiamine on the levels of these identified protein biomarkers in the human urine has also been observed. Assessment of the levels of these biomarkers will be helpful in not only early diagnosis but also prognosis of diabetes mellitus type 2.http://dx.doi.org/10.1155/2015/150176 |
| spellingShingle | Samreen Riaz Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 Journal of Diabetes Research |
| title | Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 |
| title_full | Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 |
| title_fullStr | Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 |
| title_full_unstemmed | Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 |
| title_short | Study of Protein Biomarkers of Diabetes Mellitus Type 2 and Therapy with Vitamin B1 |
| title_sort | study of protein biomarkers of diabetes mellitus type 2 and therapy with vitamin b1 |
| url | http://dx.doi.org/10.1155/2015/150176 |
| work_keys_str_mv | AT samreenriaz studyofproteinbiomarkersofdiabetesmellitustype2andtherapywithvitaminb1 |