Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study
Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2014/549162 |
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| author | Lv Han Liu Zhaohui Yan Fei Li Ting Zhao Pengfei Du Wang Dong Cheng Guo Pengde Han Xiaoyi Wang Xiao Li Rui Wang Zhenchang |
| author_facet | Lv Han Liu Zhaohui Yan Fei Li Ting Zhao Pengfei Du Wang Dong Cheng Guo Pengde Han Xiaoyi Wang Xiao Li Rui Wang Zhenchang |
| author_sort | Lv Han |
| collection | DOAJ |
| description | Numerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n=42) and age-, sex-, and education-matched normal control subjects (n=42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients. |
| format | Article |
| id | doaj-art-2165adb6c3384cc6bfb1ce8db895f9db |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-2165adb6c3384cc6bfb1ce8db895f9db2025-02-03T06:00:57ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/549162549162Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI StudyLv Han0Liu Zhaohui1Yan Fei2Li Ting3Zhao Pengfei4Du Wang5Dong Cheng6Guo Pengde7Han Xiaoyi8Wang Xiao9Li Rui10Wang Zhenchang11Department of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Radiology Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaNumerous investigations studying the brain functional activity of the tinnitus patients have indicated that neurological changes are important findings of this kind of disease. However, the pulsatile tinnitus (PT) patients were excluded in previous studies because of the totally different mechanisms of the two subtype tinnitus. The aim of this study is to investigate whether altered baseline brain activity presents in patients with PT using resting-state functional magnetic resonance imaging (rs-fMRI) technique. The present study used unilateral PT patients (n=42) and age-, sex-, and education-matched normal control subjects (n=42) to investigate the changes in structural and amplitude of low-frequency (ALFF) of the brain. Also, we analyzed the relationships between these changes with clinical data of the PT patients. Compared with normal controls, PT patients did not show any structural changes. PT patients showed significant increased ALFF in the bilateral precuneus, and bilateral inferior frontal gyrus (IFG) and decreased ALFF in multiple occipital areas. Moreover, the increased THI score and PT duration was correlated with increased ALFF in precuneus and bilateral IFG. The abnormalities of spontaneous brain activity reflected by ALFF measurements in the absence of structural changes may provide insights into the neural reorganization in PT patients.http://dx.doi.org/10.1155/2014/549162 |
| spellingShingle | Lv Han Liu Zhaohui Yan Fei Li Ting Zhao Pengfei Du Wang Dong Cheng Guo Pengde Han Xiaoyi Wang Xiao Li Rui Wang Zhenchang Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study Neural Plasticity |
| title | Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study |
| title_full | Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study |
| title_fullStr | Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study |
| title_full_unstemmed | Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study |
| title_short | Abnormal Baseline Brain Activity in Patients with Pulsatile Tinnitus: A Resting-State fMRI Study |
| title_sort | abnormal baseline brain activity in patients with pulsatile tinnitus a resting state fmri study |
| url | http://dx.doi.org/10.1155/2014/549162 |
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