Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy
Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the w...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2014/450428 |
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| author | Enzo D’Ambrosio Paolo Tortorella Ludovico Iannetti |
| author_facet | Enzo D’Ambrosio Paolo Tortorella Ludovico Iannetti |
| author_sort | Enzo D’Ambrosio |
| collection | DOAJ |
| description | Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. A review on the factors implicated so far in the pathogenesis of inflammatory choroidal neovascularization was performed. Also we reported the success rate of single studies concerning the therapies of choroidal neovascularization secondary to uveitis during the last decade: photodynamic therapy, intravitreal bevacizumab, and intravitreal ranibizumab, besides steroidal and immunosuppressive therapy. Hereby a standardization of the therapeutic approach is proposed. |
| format | Article |
| id | doaj-art-2161178fa47c48bbb7fe57fb1846c481 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-2161178fa47c48bbb7fe57fb1846c4812025-02-03T05:57:40ZengWileyJournal of Ophthalmology2090-004X2090-00582014-01-01201410.1155/2014/450428450428Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the TherapyEnzo D’Ambrosio0Paolo Tortorella1Ludovico Iannetti2Department of Ophthalmology, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Ophthalmology, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Ophthalmology, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyInflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. A review on the factors implicated so far in the pathogenesis of inflammatory choroidal neovascularization was performed. Also we reported the success rate of single studies concerning the therapies of choroidal neovascularization secondary to uveitis during the last decade: photodynamic therapy, intravitreal bevacizumab, and intravitreal ranibizumab, besides steroidal and immunosuppressive therapy. Hereby a standardization of the therapeutic approach is proposed.http://dx.doi.org/10.1155/2014/450428 |
| spellingShingle | Enzo D’Ambrosio Paolo Tortorella Ludovico Iannetti Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy Journal of Ophthalmology |
| title | Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy |
| title_full | Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy |
| title_fullStr | Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy |
| title_full_unstemmed | Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy |
| title_short | Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy |
| title_sort | management of uveitis related choroidal neovascularization from the pathogenesis to the therapy |
| url | http://dx.doi.org/10.1155/2014/450428 |
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