Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease

Reduction of orexin-expressing neurons and a unique sleep phenotype in the Tg-SwDI mouse model of Alzheimer’s disease

Sleep disturbances are common in Alzheimer’s disease (AD) and AD-related dementia (ADRD). We performed a sleep study on Tg-SwDI mice, a cerebral amyloid angiopathy (CAA) model, and age-matched wild-type (WT) control mice. The results showed that at 12 months of age, the hemizygous Tg-SwDI mice spent...

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Bibliographic Details
Main Authors: Yan Wu, Narayan R. Bhat, Meng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
sleep
Alzheimer’s disease
orexin
cerebral amyloid angiopathy
Tg-SwDI
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1529769/full
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