Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing
Modern techniques of thin film deposition (e.g., atomic layer deposition [ALD]) have paved the way for the modification of the surface of target substrates with thin films, nanoparticles, or other types of nanomaterials. This novel way can improve the base material's properties and enhance spec...
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Elsevier
2025-02-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025005572 |
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| author | Sarah Hashemi Astaneh Leonardo P. Faverani Harshdeep Bhatia Eduardo Dallazen Monique Gonçalves Costa Edilson Ervolino Valentim A.R. Barão Cortino Sukotjo Christos G. Takoudis |
| author_facet | Sarah Hashemi Astaneh Leonardo P. Faverani Harshdeep Bhatia Eduardo Dallazen Monique Gonçalves Costa Edilson Ervolino Valentim A.R. Barão Cortino Sukotjo Christos G. Takoudis |
| author_sort | Sarah Hashemi Astaneh |
| collection | DOAJ |
| description | Modern techniques of thin film deposition (e.g., atomic layer deposition [ALD]) have paved the way for the modification of the surface of target substrates with thin films, nanoparticles, or other types of nanomaterials. This novel way can improve the base material's properties and enhance specific properties through adding functionalized groups to the surface. In this study, ALD of silver was conducted on commercially available Type I collagen membrane to improve its bioactivity and promote bone healing. Two different sample groups were studied: pristine collagen and silver-coated collagen via ALD (Ag/Collagen). Chemical and morphological changes of the collagen membrane were investigated with X-ray photoelectron spectroscopy and scanning electron microscopy and the bioactivity of functionalized collagen with silver was studied in vitro and in vivo. Nano-islands of silver were obtained on collagen fibrils with an average diameter of ∼16 nm. Comparison of gingival cells cultured on pristine collagen, and silver-coated collagen, demonstrated that the attained silver nanoparticle size and concentration are below the toxicity level of silver. In vivo assessment in rat model showed the biocompatibility of the Ag/Collagen, and greater new bone formation compared to control. This novel solvent-free method can be used to functionalize sensitive materials used in surgeries as bone grafting agents to enhance osteopromotive properties without any adverse effects to the cellular environment. |
| format | Article |
| id | doaj-art-214ab78aaea848af94a8ff25c09fd840 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-214ab78aaea848af94a8ff25c09fd8402025-01-28T04:14:46ZengElsevierHeliyon2405-84402025-02-01113e42177Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healingSarah Hashemi Astaneh0Leonardo P. Faverani1Harshdeep Bhatia2Eduardo Dallazen3Monique Gonçalves Costa4Edilson Ervolino5Valentim A.R. Barão6Cortino Sukotjo7Christos G. Takoudis8Chemical Engineering Department, University of Illinois Chicago, Chicago, IL, 60607, USADepartment of Diagnosis and Surgery, Sao Paulo State University (UNESP), Araçatuba, São Paulo, 16015-050, Brazil; Department of Oral Diagnosis, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, BrazilChemical Engineering Department, University of Illinois Chicago, Chicago, IL, 60607, USADepartment of Diagnosis and Surgery, Sao Paulo State University (UNESP), Araçatuba, São Paulo, 16015-050, BrazilDepartment of Diagnosis and Surgery, Sao Paulo State University (UNESP), Araçatuba, São Paulo, 16015-050, BrazilDepartment of Basic Sciences, Sao Paulo State University (UNESP), Araçatuba, São Paulo, 16015-050, BrazilDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, BrazilDepartment of Prosthodontics, School of Dental Medicine, University of Pittsburgh, PA, 15213, USA; Corresponding author.Chemical Engineering Department, University of Illinois Chicago, Chicago, IL, 60607, USA; Biomedical Engineering Department, University of Illinois Chicago, Chicago, IL, 60607, USA; Corresponding author. Chemical and Biomedical Engineering Departments, University of Illinois Chicago, Chicago, IL, 60607, USA.Modern techniques of thin film deposition (e.g., atomic layer deposition [ALD]) have paved the way for the modification of the surface of target substrates with thin films, nanoparticles, or other types of nanomaterials. This novel way can improve the base material's properties and enhance specific properties through adding functionalized groups to the surface. In this study, ALD of silver was conducted on commercially available Type I collagen membrane to improve its bioactivity and promote bone healing. Two different sample groups were studied: pristine collagen and silver-coated collagen via ALD (Ag/Collagen). Chemical and morphological changes of the collagen membrane were investigated with X-ray photoelectron spectroscopy and scanning electron microscopy and the bioactivity of functionalized collagen with silver was studied in vitro and in vivo. Nano-islands of silver were obtained on collagen fibrils with an average diameter of ∼16 nm. Comparison of gingival cells cultured on pristine collagen, and silver-coated collagen, demonstrated that the attained silver nanoparticle size and concentration are below the toxicity level of silver. In vivo assessment in rat model showed the biocompatibility of the Ag/Collagen, and greater new bone formation compared to control. This novel solvent-free method can be used to functionalize sensitive materials used in surgeries as bone grafting agents to enhance osteopromotive properties without any adverse effects to the cellular environment.http://www.sciencedirect.com/science/article/pii/S2405844025005572Collagen functionalizationSilver nano-islandsAtomic layer depositionBone healing |
| spellingShingle | Sarah Hashemi Astaneh Leonardo P. Faverani Harshdeep Bhatia Eduardo Dallazen Monique Gonçalves Costa Edilson Ervolino Valentim A.R. Barão Cortino Sukotjo Christos G. Takoudis Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing Heliyon Collagen functionalization Silver nano-islands Atomic layer deposition Bone healing |
| title | Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing |
| title_full | Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing |
| title_fullStr | Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing |
| title_full_unstemmed | Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing |
| title_short | Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing |
| title_sort | functionalization of collagen fiber with nano islands of silver via atomic layer deposition to promote bone healing |
| topic | Collagen functionalization Silver nano-islands Atomic layer deposition Bone healing |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025005572 |
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