Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model
In the present pilot study, the authors morphologically investigated sandblasted, acid-etched surfaces (SLA) at very early experimental times. The tested devices were titanium plate-like implants with flattened wide lateral sides and jagged narrow sides. Because of these implant shape and placement...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/349842 |
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| author | Ester Orsini Stefano Salgarello Désirée Martini Beatrice Bacchelli Marilisa Quaranta Luciano Pisoni Emma Bellei Monika Joechler Vittoria Ottani |
| author_facet | Ester Orsini Stefano Salgarello Désirée Martini Beatrice Bacchelli Marilisa Quaranta Luciano Pisoni Emma Bellei Monika Joechler Vittoria Ottani |
| author_sort | Ester Orsini |
| collection | DOAJ |
| description | In the present pilot study, the authors morphologically investigated sandblasted, acid-etched surfaces (SLA) at very early experimental times. The tested devices were titanium plate-like implants with flattened wide lateral sides and jagged narrow sides. Because of these implant shape and placement site, the device gained a firm mechanical stability but the largest portion of the implant surface lacked direct contact with host bone and faced a wide peri-implant space rich in marrow tissue, intentionally created in order to study the interfacial interaction between metal surface and biological microenvironment. The insertion of titanium devices into the proximal tibia elicited a sequence of healing events. Newly formed bone proceeded through an early distance osteogenesis, common to both surfaces, and a delayed contact osteogenesis which seemed to follow different patterns at the two surfaces. In fact, SLA devices showed a more osteoconductive behavior retaining a less dense blood clot, which might be earlier and more easily replaced, and leading to a surface-conditioning layer which promotes osteogenic cell differentiation and appositional new bone deposition at the titanium surface. This model system is expected to provide a starting point for further investigations which clarify the early cellular and biomolecular events occurring at the metal surface. |
| format | Article |
| id | doaj-art-2149d4c3201743d6ad12db4f722e540f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | The Scientific World Journal |
| spelling | doaj-art-2149d4c3201743d6ad12db4f722e540f2025-02-03T05:50:25ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/349842349842Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit ModelEster Orsini0Stefano Salgarello1Désirée Martini2Beatrice Bacchelli3Marilisa Quaranta4Luciano Pisoni5Emma Bellei6Monika Joechler7Vittoria Ottani8Department of Human Anatomical Sciences and Physiopathology of Locomotor Apparatus, Human Anatomy Section, University of Bologna, via Irnerio 48, 40126 Bologna, ItalyDental School, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, ItalyDepartment of Human Anatomical Sciences and Physiopathology of Locomotor Apparatus, Human Anatomy Section, University of Bologna, via Irnerio 48, 40126 Bologna, ItalyDepartment of Human Anatomical Sciences and Physiopathology of Locomotor Apparatus, Human Anatomy Section, University of Bologna, via Irnerio 48, 40126 Bologna, ItalyDepartment of Human Anatomical Sciences and Physiopathology of Locomotor Apparatus, Human Anatomy Section, University of Bologna, via Irnerio 48, 40126 Bologna, ItalyDepartment of Veterinary Medical Sciences, Faculty of Veterinary Medicine, University of Bologna, via Tolara di Sopra 50, 40064 Ozzano dell’Emilia, Bologna, ItalyDepartment of Veterinary Medical Sciences, Faculty of Veterinary Medicine, University of Bologna, via Tolara di Sopra 50, 40064 Ozzano dell’Emilia, Bologna, ItalyDepartment of Veterinary Medical Sciences, Faculty of Veterinary Medicine, University of Bologna, via Tolara di Sopra 50, 40064 Ozzano dell’Emilia, Bologna, ItalyDepartment of Human Anatomical Sciences and Physiopathology of Locomotor Apparatus, Human Anatomy Section, University of Bologna, via Irnerio 48, 40126 Bologna, ItalyIn the present pilot study, the authors morphologically investigated sandblasted, acid-etched surfaces (SLA) at very early experimental times. The tested devices were titanium plate-like implants with flattened wide lateral sides and jagged narrow sides. Because of these implant shape and placement site, the device gained a firm mechanical stability but the largest portion of the implant surface lacked direct contact with host bone and faced a wide peri-implant space rich in marrow tissue, intentionally created in order to study the interfacial interaction between metal surface and biological microenvironment. The insertion of titanium devices into the proximal tibia elicited a sequence of healing events. Newly formed bone proceeded through an early distance osteogenesis, common to both surfaces, and a delayed contact osteogenesis which seemed to follow different patterns at the two surfaces. In fact, SLA devices showed a more osteoconductive behavior retaining a less dense blood clot, which might be earlier and more easily replaced, and leading to a surface-conditioning layer which promotes osteogenic cell differentiation and appositional new bone deposition at the titanium surface. This model system is expected to provide a starting point for further investigations which clarify the early cellular and biomolecular events occurring at the metal surface.http://dx.doi.org/10.1100/2012/349842 |
| spellingShingle | Ester Orsini Stefano Salgarello Désirée Martini Beatrice Bacchelli Marilisa Quaranta Luciano Pisoni Emma Bellei Monika Joechler Vittoria Ottani Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model The Scientific World Journal |
| title | Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model |
| title_full | Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model |
| title_fullStr | Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model |
| title_full_unstemmed | Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model |
| title_short | Early Healing Events around Titanium Implant Devices with Different Surface Microtopography: A Pilot Study in an In Vivo Rabbit Model |
| title_sort | early healing events around titanium implant devices with different surface microtopography a pilot study in an in vivo rabbit model |
| url | http://dx.doi.org/10.1100/2012/349842 |
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