The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis
Colorectal cancer (CRC) remains one of the top cancers in the world. Although early detection improves the survival rate to around 90%, late detection would mean the need to use chemotherapy or radiotherapy, especially if surgery is not feasible. 5-fluorouracil (5-FU) is one of the common anti-canc...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
HH Publisher
2023-07-01
|
| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/827 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832541390716796928 |
|---|---|
| author | Alexandra Arcilla Xin Hui Sim Jia Ying Cheam Jodi Woan-Fei Law Vengadesh Letchumanan Yatinesh Kumari Satoshi Ogawa Sunny Hei Wong Kok-Gan Chan Loh Teng-Hern Tan |
| author_facet | Alexandra Arcilla Xin Hui Sim Jia Ying Cheam Jodi Woan-Fei Law Vengadesh Letchumanan Yatinesh Kumari Satoshi Ogawa Sunny Hei Wong Kok-Gan Chan Loh Teng-Hern Tan |
| author_sort | Alexandra Arcilla Xin Hui Sim |
| collection | DOAJ |
| description |
Colorectal cancer (CRC) remains one of the top cancers in the world. Although early detection improves the survival rate to around 90%, late detection would mean the need to use chemotherapy or radiotherapy, especially if surgery is not feasible. 5-fluorouracil (5-FU) is one of the common anti-cancer drugs used in treating CRC. It is the drug that has the greatest efficacy on CRC. Although it improves the survival rate, it has many detrimental side effects. One of these side effects is intestinal mucositis. It is described as having reduced villus height, villus atrophy, crypt fissure, abdominal discomfort, diarrhoea, and weight loss. Clinically, there is no conclusive treatment therapy for mucositis. This is possibly due to the complex mechanism of the pathobiology of intestinal mucositis that includes the production of pro-inflammatory cytokines and increased epithelial cell apoptosis. 5-FU itself is known to cause gut dysbiosis. Current studies revealed probiotics play a role in attenuating this inflammatory process of intestinal mucositis by reversing gut dysbiosis, reducing the expression of pro-inflammatory cytokines, and reducing intestinal damage. This review outlines the latest evidence supporting probiotic use in ameliorating 5-FU induced intestinal mucositis, thereby promoting good health and well-being in colorectal cancer patients receiving 5-FU chemotherapy.
|
| format | Article |
| id | doaj-art-2145dad5bcbc4f5e91aa6c69d0e8046b |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-2145dad5bcbc4f5e91aa6c69d0e8046b2025-02-04T08:39:51ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492023-07-016110.36877/pmmb.a0000339The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal MucositisAlexandra Arcilla Xin Hui SimJia Ying CheamJodi Woan-Fei LawVengadesh LetchumananYatinesh KumariSatoshi OgawaSunny Hei WongKok-Gan ChanLoh Teng-Hern Tan Colorectal cancer (CRC) remains one of the top cancers in the world. Although early detection improves the survival rate to around 90%, late detection would mean the need to use chemotherapy or radiotherapy, especially if surgery is not feasible. 5-fluorouracil (5-FU) is one of the common anti-cancer drugs used in treating CRC. It is the drug that has the greatest efficacy on CRC. Although it improves the survival rate, it has many detrimental side effects. One of these side effects is intestinal mucositis. It is described as having reduced villus height, villus atrophy, crypt fissure, abdominal discomfort, diarrhoea, and weight loss. Clinically, there is no conclusive treatment therapy for mucositis. This is possibly due to the complex mechanism of the pathobiology of intestinal mucositis that includes the production of pro-inflammatory cytokines and increased epithelial cell apoptosis. 5-FU itself is known to cause gut dysbiosis. Current studies revealed probiotics play a role in attenuating this inflammatory process of intestinal mucositis by reversing gut dysbiosis, reducing the expression of pro-inflammatory cytokines, and reducing intestinal damage. This review outlines the latest evidence supporting probiotic use in ameliorating 5-FU induced intestinal mucositis, thereby promoting good health and well-being in colorectal cancer patients receiving 5-FU chemotherapy. https://journals.hh-publisher.com/index.php/pmmb/article/view/827 |
| spellingShingle | Alexandra Arcilla Xin Hui Sim Jia Ying Cheam Jodi Woan-Fei Law Vengadesh Letchumanan Yatinesh Kumari Satoshi Ogawa Sunny Hei Wong Kok-Gan Chan Loh Teng-Hern Tan The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis Progress in Microbes and Molecular Biology |
| title | The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis |
| title_full | The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis |
| title_fullStr | The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis |
| title_full_unstemmed | The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis |
| title_short | The Ameliorative Role of Probiotics in 5-fluorouracil Induced Intestinal Mucositis |
| title_sort | ameliorative role of probiotics in 5 fluorouracil induced intestinal mucositis |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/827 |
| work_keys_str_mv | AT alexandraarcillaxinhuisim theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT jiayingcheam theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT jodiwoanfeilaw theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT vengadeshletchumanan theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT yatineshkumari theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT satoshiogawa theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT sunnyheiwong theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT kokganchan theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT lohtengherntan theameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT alexandraarcillaxinhuisim ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT jiayingcheam ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT jodiwoanfeilaw ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT vengadeshletchumanan ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT yatineshkumari ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT satoshiogawa ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT sunnyheiwong ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT kokganchan ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis AT lohtengherntan ameliorativeroleofprobioticsin5fluorouracilinducedintestinalmucositis |