Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections
Posaconazole is the newest antifungal agent to be approved for use in Canada. With excellent in vitro activity against a broad spectrum of yeasts and filamentous fungi, as well as having a well-tolerated oral formulation, posaconazole offers many potential advantages. Of particular interest are its...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2008/825901 |
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| _version_ | 1832563133371121664 |
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| author | Andrea V Page W Conrad Liles |
| author_facet | Andrea V Page W Conrad Liles |
| author_sort | Andrea V Page |
| collection | DOAJ |
| description | Posaconazole is the newest antifungal agent to be approved for use in Canada. With excellent in vitro activity against a broad spectrum of yeasts and filamentous fungi, as well as having a well-tolerated oral formulation, posaconazole offers many potential advantages. Of particular interest are its seemingly lower potential for cross-resistance with other azoles and its activity (unique among oral antifungal agents) against the zygomycetes. As the incidence of both common and uncommon fungal infections increases commensurate with the growing population of immunocompromised individuals, posaconazole may ultimately become an important therapeutic option. The present article reviews the in vitro and in vivo data describing its activity, and focuses on both the proven and the potential clinical applications of this new triazole agent. |
| format | Article |
| id | doaj-art-213a2bd7175d41ac985dfc932325cf56 |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-213a2bd7175d41ac985dfc932325cf562025-02-03T01:20:47ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322008-01-0119429730510.1155/2008/825901Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal InfectionsAndrea V Page0W Conrad Liles1Division of Infectious Diseases, University Health Network, CanadaDivision of Infectious Diseases, University Health Network, CanadaPosaconazole is the newest antifungal agent to be approved for use in Canada. With excellent in vitro activity against a broad spectrum of yeasts and filamentous fungi, as well as having a well-tolerated oral formulation, posaconazole offers many potential advantages. Of particular interest are its seemingly lower potential for cross-resistance with other azoles and its activity (unique among oral antifungal agents) against the zygomycetes. As the incidence of both common and uncommon fungal infections increases commensurate with the growing population of immunocompromised individuals, posaconazole may ultimately become an important therapeutic option. The present article reviews the in vitro and in vivo data describing its activity, and focuses on both the proven and the potential clinical applications of this new triazole agent.http://dx.doi.org/10.1155/2008/825901 |
| spellingShingle | Andrea V Page W Conrad Liles Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections |
| title_full | Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections |
| title_fullStr | Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections |
| title_full_unstemmed | Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections |
| title_short | Posaconazole: A New Agent for the Prevention and Management of Severe, Refractory or Invasive Fungal Infections |
| title_sort | posaconazole a new agent for the prevention and management of severe refractory or invasive fungal infections |
| url | http://dx.doi.org/10.1155/2008/825901 |
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