Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives
Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using 1H NMR, IR, and mass analysis. In...
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/718023 |
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| author | Selvaraj Jubie Rajamanickam Gayathri Rajagopal Kalirajan |
| author_facet | Selvaraj Jubie Rajamanickam Gayathri Rajagopal Kalirajan |
| author_sort | Selvaraj Jubie |
| collection | DOAJ |
| description | Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using 1H NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. For the purpose, different screening methods such as open field exploratory behavior test, rota rod test, grip strength test, beam walk test, and photo actometer test were performed. Ethidium bromide induction showed muscle weakness; muscle discoordination; loss of locomotor activity, and so forth, the synthesized drugs reversed all the above-mentioned neuromuscular disorders caused by ethidium bromide administration. |
| format | Article |
| id | doaj-art-212f54c5d2ae493cbbdc8c08a47fbb6c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-212f54c5d2ae493cbbdc8c08a47fbb6c2025-02-03T01:23:15ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/718023718023Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione DerivativesSelvaraj Jubie0Rajamanickam Gayathri1Rajagopal Kalirajan2Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Off Campus, JSS University, Mysore 570015, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, Off Campus, JSS University, Mysore 570015, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, Off Campus, JSS University, Mysore 570015, IndiaQuinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid was reacted with three different ketones and formaldehyde to give the corresponding Mannich bases in satisfactory yield. Their structures were confirmed by using 1H NMR, IR, and mass analysis. In pharmacological evaluation, the synthesized compounds showed its curative effect against ethidium-bromide-induced demyelination in rats. For the purpose, different screening methods such as open field exploratory behavior test, rota rod test, grip strength test, beam walk test, and photo actometer test were performed. Ethidium bromide induction showed muscle weakness; muscle discoordination; loss of locomotor activity, and so forth, the synthesized drugs reversed all the above-mentioned neuromuscular disorders caused by ethidium bromide administration.http://dx.doi.org/10.1100/2012/718023 |
| spellingShingle | Selvaraj Jubie Rajamanickam Gayathri Rajagopal Kalirajan Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives The Scientific World Journal |
| title | Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives |
| title_full | Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives |
| title_fullStr | Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives |
| title_full_unstemmed | Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives |
| title_short | Synthesis and Neuropharmacological Evaluation of Some Novel Quinoxaline 2, 3-Dione Derivatives |
| title_sort | synthesis and neuropharmacological evaluation of some novel quinoxaline 2 3 dione derivatives |
| url | http://dx.doi.org/10.1100/2012/718023 |
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