The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer
Introduction: The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for nasopharyngeal carcinoma (NPC) continues to be debated. This study was conducted to enhance the accuracy of its prognostic value through a single-centre analysis. Methods: Ninety-seven patients with NPC who receive...
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Izzet Baysal Training and Research Hospital
2025-01-01
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| author | Mustafa Kandaz Atalay Balsak Hatice Bengü Çobanoğlu |
| author_facet | Mustafa Kandaz Atalay Balsak Hatice Bengü Çobanoğlu |
| author_sort | Mustafa Kandaz |
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Introduction: The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for nasopharyngeal carcinoma (NPC) continues to be debated. This study was conducted to enhance the accuracy of its prognostic value through a single-centre analysis.
Methods: Ninety-seven patients with NPC who received adjuvant radiotherapy between 1998 and 2022 were analyzed retrospectively.
Results: The study included a total of 97 patients who were treated for NPC and had available data. In 54 (56%) patients the NLR was ≤3 and in 43 (44%) the NLR was >3. The mean age of the patients was 49.64±14.51 (range: 12-82) years. Four patients were ≤18 years old and 93 patients were >19 years old. Sixty-three (65%) patients were male, 34 (35%) patients were female. For stage I patients, NLR was ≤3 in 2 (2%) and >3 in 2 (2%) patients. For stage II patients, NLR was ≤3 in 10 (11%) and >3 in 8 (8%) patients. For stage III patients, NLR was ≤3 in 29 (30%) and >3 in 25 (26%) patients. For stage IVA patients, NLR was ≤3 in 12 (12%) and >3 in 8 (8%) patients. For stage IVB patients, NLR was >3 in 1 (1%). The follow-up period was 79.4±72.1 (2-279) months. In all patients, mean overall survival (OS) was 159.37±13.66 (132.97-185.76) months, median 205±31.11 (144-265.99) months, The 1-, 2- , 3- and 5-year survival rates were 87.3%, 81.5%, 74.3%, and 65.3%, respectively. In general, 54 (56%) of the patients had NLR ≤3, while 43 (44%) had NLR >3. Mean survival times were 169.72±14.2 (95%CI 141.86-197.56) and 133.88±18.95 (95%CI 96.72-171.03) months for NLR ≤3 and NLR >3 patients, respectively. Median survival time was 223 months for NLR ≤3 patients, whereas it was 118±66.11 (95%CI 0-247.58) for >3 patients. The 1-, 2-, 3- and 5- year survival rates were 92.6%, 86.4%, 82% and 72.3% for NLR ≤3 and 80.3%, 75.6%, 65% and 56.8% for NLR >3 patients, respectively, indicating statistical significance (p=0.047).
Conclusion: In NPC, a pre-treatment NLR above three indicates an unfavorable prognosis in survival and may be a valuable prognostic biomarker. A large-scale prospective study is necessary to validate the prognostic significance of NLR in NPC patients and to determine precise cut-off values.
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| format | Article |
| id | doaj-art-212af7752c3241ef8dae92821b02f9b7 |
| institution | Kabale University |
| issn | 2979-9538 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Izzet Baysal Training and Research Hospital |
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| series | Northwestern Medical Journal |
| spelling | doaj-art-212af7752c3241ef8dae92821b02f9b72025-02-04T12:17:09ZengIzzet Baysal Training and Research HospitalNorthwestern Medical Journal2979-95382025-01-015110.54307/2025.NWMJ.77The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancerMustafa Kandaz0https://orcid.org/0000-0003-1106-6227Atalay Balsak1https://orcid.org/0009-0005-7459-3165Hatice Bengü Çobanoğlu2https://orcid.org/0000-0003-3701-1697Department of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, TürkiyeDepartment of Radiation Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, TürkiyeDepartment of Otorhinolaryngology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Türkiye Introduction: The prognostic value of the neutrophil-to-lymphocyte ratio (NLR) for nasopharyngeal carcinoma (NPC) continues to be debated. This study was conducted to enhance the accuracy of its prognostic value through a single-centre analysis. Methods: Ninety-seven patients with NPC who received adjuvant radiotherapy between 1998 and 2022 were analyzed retrospectively. Results: The study included a total of 97 patients who were treated for NPC and had available data. In 54 (56%) patients the NLR was ≤3 and in 43 (44%) the NLR was >3. The mean age of the patients was 49.64±14.51 (range: 12-82) years. Four patients were ≤18 years old and 93 patients were >19 years old. Sixty-three (65%) patients were male, 34 (35%) patients were female. For stage I patients, NLR was ≤3 in 2 (2%) and >3 in 2 (2%) patients. For stage II patients, NLR was ≤3 in 10 (11%) and >3 in 8 (8%) patients. For stage III patients, NLR was ≤3 in 29 (30%) and >3 in 25 (26%) patients. For stage IVA patients, NLR was ≤3 in 12 (12%) and >3 in 8 (8%) patients. For stage IVB patients, NLR was >3 in 1 (1%). The follow-up period was 79.4±72.1 (2-279) months. In all patients, mean overall survival (OS) was 159.37±13.66 (132.97-185.76) months, median 205±31.11 (144-265.99) months, The 1-, 2- , 3- and 5-year survival rates were 87.3%, 81.5%, 74.3%, and 65.3%, respectively. In general, 54 (56%) of the patients had NLR ≤3, while 43 (44%) had NLR >3. Mean survival times were 169.72±14.2 (95%CI 141.86-197.56) and 133.88±18.95 (95%CI 96.72-171.03) months for NLR ≤3 and NLR >3 patients, respectively. Median survival time was 223 months for NLR ≤3 patients, whereas it was 118±66.11 (95%CI 0-247.58) for >3 patients. The 1-, 2-, 3- and 5- year survival rates were 92.6%, 86.4%, 82% and 72.3% for NLR ≤3 and 80.3%, 75.6%, 65% and 56.8% for NLR >3 patients, respectively, indicating statistical significance (p=0.047). Conclusion: In NPC, a pre-treatment NLR above three indicates an unfavorable prognosis in survival and may be a valuable prognostic biomarker. A large-scale prospective study is necessary to validate the prognostic significance of NLR in NPC patients and to determine precise cut-off values. https://nwmedj.org/article/view/77nasopharyngeal carcinomaneutrophil-to-lymphocyte ratiosurvival |
| spellingShingle | Mustafa Kandaz Atalay Balsak Hatice Bengü Çobanoğlu The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer Northwestern Medical Journal nasopharyngeal carcinoma neutrophil-to-lymphocyte ratio survival |
| title | The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer |
| title_full | The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer |
| title_fullStr | The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer |
| title_full_unstemmed | The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer |
| title_short | The prognostic value of neutrophil-to-lymphocyte ratio in nasopharyngeal cancer |
| title_sort | prognostic value of neutrophil to lymphocyte ratio in nasopharyngeal cancer |
| topic | nasopharyngeal carcinoma neutrophil-to-lymphocyte ratio survival |
| url | https://nwmedj.org/article/view/77 |
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