Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease
Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was first proposed as early as the 1980s following the di...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/582352 |
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| author | Jennifer C. Byrne Joan Ní Gabhann Elisa Lazzari Rebecca Mahony Siobhán Smith Kevin Stacey Claire Wynne Caroline A. Jefferies |
| author_facet | Jennifer C. Byrne Joan Ní Gabhann Elisa Lazzari Rebecca Mahony Siobhán Smith Kevin Stacey Claire Wynne Caroline A. Jefferies |
| author_sort | Jennifer C. Byrne |
| collection | DOAJ |
| description | Genetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was first proposed as early as the 1980s following the discovery that SLE macrophages were defective in their ability to clear apoptotic cell debris, thus prolonging exposure of potential autoantigens to the adaptive immune response. More recently, there is an emerging appreciation of the contribution both monocytes and macrophages play in orchestrating immune responses with perturbations in their activation or regulation leading to immune dysregulation. This paper will focus on understanding the relevance of genes identified as being associated with innate immune function of monocytes and macrophages and development of SLE, particularly with respect to their role in (1) immune complex (IC) recognition and clearance, (2) nucleic acid recognition via toll-like receptors (TLRs) and downstream signalling, and (3) interferon signalling. Particular attention will be paid to the functional consequences these genetic associations have for disease susceptibility or pathogenesis. |
| format | Article |
| id | doaj-art-2126a4e9a9064fe8a8904e35fda5ea07 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-2126a4e9a9064fe8a8904e35fda5ea072025-08-20T03:54:47ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/582352582352Genetics of SLE: Functional Relevance for Monocytes/Macrophages in DiseaseJennifer C. Byrne0Joan Ní Gabhann1Elisa Lazzari2Rebecca Mahony3Siobhán Smith4Kevin Stacey5Claire Wynne6Caroline A. Jefferies7Molecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandMolecular and Cellular Therapeutics and RCSI Research Institute, Royal College of Surgeons in Ireland, Dublin 2, IrelandGenetic studies in the last 5 years have greatly facilitated our understanding of how the dysregulation of diverse components of the innate immune system contributes to pathophysiology of SLE. A role for macrophages in the pathogenesis of SLE was first proposed as early as the 1980s following the discovery that SLE macrophages were defective in their ability to clear apoptotic cell debris, thus prolonging exposure of potential autoantigens to the adaptive immune response. More recently, there is an emerging appreciation of the contribution both monocytes and macrophages play in orchestrating immune responses with perturbations in their activation or regulation leading to immune dysregulation. This paper will focus on understanding the relevance of genes identified as being associated with innate immune function of monocytes and macrophages and development of SLE, particularly with respect to their role in (1) immune complex (IC) recognition and clearance, (2) nucleic acid recognition via toll-like receptors (TLRs) and downstream signalling, and (3) interferon signalling. Particular attention will be paid to the functional consequences these genetic associations have for disease susceptibility or pathogenesis.http://dx.doi.org/10.1155/2012/582352 |
| spellingShingle | Jennifer C. Byrne Joan Ní Gabhann Elisa Lazzari Rebecca Mahony Siobhán Smith Kevin Stacey Claire Wynne Caroline A. Jefferies Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease Clinical and Developmental Immunology |
| title | Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease |
| title_full | Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease |
| title_fullStr | Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease |
| title_full_unstemmed | Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease |
| title_short | Genetics of SLE: Functional Relevance for Monocytes/Macrophages in Disease |
| title_sort | genetics of sle functional relevance for monocytes macrophages in disease |
| url | http://dx.doi.org/10.1155/2012/582352 |
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