Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides
A series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a–5o were synthesized and characterized. The synthesized compounds (5a–5o) were screened in vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. According to MTT results, comp...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/2189743 |
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| author | Shengxian Zhao Yin Cao Zhenzhen Cui Jiayun Zhang Zhixiang Pan Hongyu Hu |
| author_facet | Shengxian Zhao Yin Cao Zhenzhen Cui Jiayun Zhang Zhixiang Pan Hongyu Hu |
| author_sort | Shengxian Zhao |
| collection | DOAJ |
| description | A series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a–5o were synthesized and characterized. The synthesized compounds (5a–5o) were screened in vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. According to MTT results, compounds 5k and 5l showed better antiproliferative activities over MCF-7 cell lines with IC50 values of 8.50 and 12.51 μM. Colony formation assay indicated 5k/5l treatment obviously inhibited the growth of MCF-7 cells and 5k/5l-induced cell cycle was arrested in the G2-M phase. Moreover, 5k/5l significantly increased the level of cleaved PARP and induced the apoptosis in MCF-7 cells. In addition, compared to Hela cells, MCF-7 cells were more sensitive to 5k/5l treatment. |
| format | Article |
| id | doaj-art-211ab76b1f26435ea19ea67c48aa99fd |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-211ab76b1f26435ea19ea67c48aa99fd2025-02-03T05:53:53ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/21897432189743Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamidesShengxian Zhao0Yin Cao1Zhenzhen Cui2Jiayun Zhang3Zhixiang Pan4Hongyu Hu5College of Science and Technology, Ningbo University, Cixi 315302, ChinaSchool of Pharmaceutical Sciences and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, South Xiang-An Road, Xiamen 361102, ChinaSchool of Pharmaceutical Sciences and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, South Xiang-An Road, Xiamen 361102, ChinaCollege of Science and Technology, Ningbo University, Cixi 315302, ChinaCollege of Science and Technology, Ningbo University, Cixi 315302, ChinaCollege of Science and Technology, Ningbo University, Cixi 315302, ChinaA series of 2-arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides 5a–5o were synthesized and characterized. The synthesized compounds (5a–5o) were screened in vitro against three breast cancer cell lines: SKBR3, MDA-MB-231, and MCF-7 cancer cell lines by the MTT assay. According to MTT results, compounds 5k and 5l showed better antiproliferative activities over MCF-7 cell lines with IC50 values of 8.50 and 12.51 μM. Colony formation assay indicated 5k/5l treatment obviously inhibited the growth of MCF-7 cells and 5k/5l-induced cell cycle was arrested in the G2-M phase. Moreover, 5k/5l significantly increased the level of cleaved PARP and induced the apoptosis in MCF-7 cells. In addition, compared to Hela cells, MCF-7 cells were more sensitive to 5k/5l treatment.http://dx.doi.org/10.1155/2020/2189743 |
| spellingShingle | Shengxian Zhao Yin Cao Zhenzhen Cui Jiayun Zhang Zhixiang Pan Hongyu Hu Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides Journal of Chemistry |
| title | Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides |
| title_full | Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides |
| title_fullStr | Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides |
| title_full_unstemmed | Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides |
| title_short | Synthesis and Biological Activity of 2-Arylidene-N-(quinolin-6-yl)hydrazine-1-carboxamides |
| title_sort | synthesis and biological activity of 2 arylidene n quinolin 6 yl hydrazine 1 carboxamides |
| url | http://dx.doi.org/10.1155/2020/2189743 |
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