Genome-Wide Association Study of Coronary Artery Disease
Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2010/790539 |
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| _version_ | 1832562245833326592 |
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| author | Naomi Ogawa Yasushi Imai Hiroyuki Morita Ryozo Nagai |
| author_facet | Naomi Ogawa Yasushi Imai Hiroyuki Morita Ryozo Nagai |
| author_sort | Naomi Ogawa |
| collection | DOAJ |
| description | Coronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips have enabled us to perform genome-wide association studies (GWAS) on a large number of subjects without bias towards any particular candidate genes. In 2007, three chip-based GWAS simultaneously revealed the significant association between common variants on chromosome 9p21 and CAD. This association was replicated among other ethnic groups and also in a meta-analysis. Further investigations have detected several other candidate loci associated with CAD. The chip-based GWAS approach has identified novel and unbiased genetic determinants of CAD and these insights provide the important direction to better understand the pathogenesis of CAD and to develop new and improved preventive measures and treatments for CAD. |
| format | Article |
| id | doaj-art-2111054d925c4e6f8202489df00d8606 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-2111054d925c4e6f8202489df00d86062025-02-03T01:23:07ZengWileyInternational Journal of Hypertension2090-03922010-01-01201010.4061/2010/790539790539Genome-Wide Association Study of Coronary Artery DiseaseNaomi Ogawa0Yasushi Imai1Hiroyuki Morita2Ryozo Nagai3Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo 113-8655, JapanCoronary artery disease (CAD) is a multifactorial disease with environmental and genetic determinants. The genetic determinants of CAD have previously been explored by the candidate gene approach. Recently, the data from the International HapMap Project and the development of dense genotyping chips have enabled us to perform genome-wide association studies (GWAS) on a large number of subjects without bias towards any particular candidate genes. In 2007, three chip-based GWAS simultaneously revealed the significant association between common variants on chromosome 9p21 and CAD. This association was replicated among other ethnic groups and also in a meta-analysis. Further investigations have detected several other candidate loci associated with CAD. The chip-based GWAS approach has identified novel and unbiased genetic determinants of CAD and these insights provide the important direction to better understand the pathogenesis of CAD and to develop new and improved preventive measures and treatments for CAD.http://dx.doi.org/10.4061/2010/790539 |
| spellingShingle | Naomi Ogawa Yasushi Imai Hiroyuki Morita Ryozo Nagai Genome-Wide Association Study of Coronary Artery Disease International Journal of Hypertension |
| title | Genome-Wide Association Study of Coronary Artery Disease |
| title_full | Genome-Wide Association Study of Coronary Artery Disease |
| title_fullStr | Genome-Wide Association Study of Coronary Artery Disease |
| title_full_unstemmed | Genome-Wide Association Study of Coronary Artery Disease |
| title_short | Genome-Wide Association Study of Coronary Artery Disease |
| title_sort | genome wide association study of coronary artery disease |
| url | http://dx.doi.org/10.4061/2010/790539 |
| work_keys_str_mv | AT naomiogawa genomewideassociationstudyofcoronaryarterydisease AT yasushiimai genomewideassociationstudyofcoronaryarterydisease AT hiroyukimorita genomewideassociationstudyofcoronaryarterydisease AT ryozonagai genomewideassociationstudyofcoronaryarterydisease |