Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users
OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Pain Research and Management |
| Online Access: | http://dx.doi.org/10.1155/2013/952082 |
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| _version_ | 1832553665276149760 |
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| author | Beatrice Setnik Veeraindar Goli Naama Levy-Cooperman Catherine Mills Megan Shram Ira Smith |
| author_facet | Beatrice Setnik Veeraindar Goli Naama Levy-Cooperman Catherine Mills Megan Shram Ira Smith |
| author_sort | Beatrice Setnik |
| collection | DOAJ |
| description | OBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally. |
| format | Article |
| id | doaj-art-21014173a3914b4da56df0a908c7dc6e |
| institution | Kabale University |
| issn | 1203-6765 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pain Research and Management |
| spelling | doaj-art-21014173a3914b4da56df0a908c7dc6e2025-02-03T05:53:31ZengWileyPain Research and Management1203-67652013-01-01184e55e6210.1155/2013/952082Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid UsersBeatrice Setnik0Veeraindar Goli1Naama Levy-Cooperman2Catherine Mills3Megan Shram4Ira Smith5Pfizer Inc, Cary, USAPfizer Inc, Cary, USAINC Research, University of Toronto, Toronto, Ontario, CanadaINC Research, University of Toronto, Toronto, Ontario, CanadaINC Research, University of Toronto, Toronto, Ontario, CanadaINC Research, University of Toronto, Toronto, Ontario, CanadaOBJECTIVE: To evaluate the pharmacodynamic (PD) effects of morphine sulfate and naltrexone hydrochloride extended-release (MSN) capsules compared with controlled-release morphine sulfate (MS) and placebo when crushed and administered intranasally.http://dx.doi.org/10.1155/2013/952082 |
| spellingShingle | Beatrice Setnik Veeraindar Goli Naama Levy-Cooperman Catherine Mills Megan Shram Ira Smith Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users Pain Research and Management |
| title | Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users |
| title_full | Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users |
| title_fullStr | Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users |
| title_full_unstemmed | Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users |
| title_short | Assessing the Subjective and Physiological Effects of Intranasally Administered Crushed Extended-Release Morphine Formulations with and without a Sequestered Naltrexone Core in Recreational Opioid Users |
| title_sort | assessing the subjective and physiological effects of intranasally administered crushed extended release morphine formulations with and without a sequestered naltrexone core in recreational opioid users |
| url | http://dx.doi.org/10.1155/2013/952082 |
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