Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity
Aim. To study the prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) as a marker of adverse cardiovascular events (CVEs) in patients with coronary artery disease (CAD) associated with abdominal obesity (AO).Material and methods. This 12-month prospective study included 68 patients...
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«FIRMA «SILICEA» LLC
2023-05-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5416 |
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| author | A. V. Svarovskaya P. A. Astanin A/ T. Teplyakov A. D. Vende O. N. Ogurkova A. A. Garganeeva |
| author_facet | A. V. Svarovskaya P. A. Astanin A/ T. Teplyakov A. D. Vende O. N. Ogurkova A. A. Garganeeva |
| author_sort | A. V. Svarovskaya |
| collection | DOAJ |
| description | Aim. To study the prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) as a marker of adverse cardiovascular events (CVEs) in patients with coronary artery disease (CAD) associated with abdominal obesity (AO).Material and methods. This 12-month prospective study included 68 patients diagnosed with CAD who were hospitalized for elective percutaneous coronary intervention (PCI). The median age was 61 [55;65] years. Depending on the presence of obesity according to the World Health Organization (1999) criteria, patients were divided into 2 groups. The 1st group included 30 patients with AO, while the 2nd group — 38 patients without obesity. Patients were measured for waist circumference and hip circumference, and waist-to-hip ratio was calculated. Lipid profile and NGAL concentration were determined. During the study, body mass index (BMI), visceral adiposity index (VAI), triglycerides (TG)/glucose index, lipid accumulation product (LAP), metabolic index (MI), TG to high-density lipoprotein cholesterol ratio (HDL-C). During this period, data was collected on the disease course and intervention outcome. After 12 months an extended examination was performed to assess the endpoints.Results. During the follow-up period, unfavorable cardiovascular events in the 1st group of patients were registered in 33,3% of patients, and in the 2nd group — in 26,3%. In the group of patients with obesity, higher values of anthropometric indices and NGAL were established. The concentration of NGAL has the highest correlation with BMI, MI, LAP and slightly less with total cholesterol and VAI levels. The analysis showed that NGAL >47,1 ng/ml is a predictor of adverse CVEs in patients with CAD and obesity after PCI.Conclusion. Thus, NGAL has the highest correlation with the following indices: BMI, MI, LAP, total cholesterol, and VAI. NGAL >47,1 ng/ml is a predictor of adverse CVEs in patients with CAD and obesity after PCI. NGAL may serve as a promising marker for predicting adverse CVEs. This biomarker already at the stage of hospitalization can assess the risk adverse outcomes in patients with CAD and AO, including those who underwent PCI. |
| format | Article |
| id | doaj-art-20f93ae92c014ebca7cd319ca1f18ae7 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-20f93ae92c014ebca7cd319ca1f18ae72025-08-20T03:57:22Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-05-0128410.15829/1560-4071-2023-54163804Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesityA. V. Svarovskaya0P. A. Astanin1A/ T. Teplyakov2A. D. Vende3O. N. Ogurkova4A. A. Garganeeva5Cardiology Research Institute, Tomsk National Research Medical CentrePirogov Russian National Research Medical University; Izmerov Re-search Institute of Occupational HealthCardiology Research Institute, Tomsk National Research Medical CentreSiberian State Medical UniversityCardiology Research Institute, Tomsk National Research Medical CentreCardiology Research Institute, Tomsk National Research Medical CentreAim. To study the prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) as a marker of adverse cardiovascular events (CVEs) in patients with coronary artery disease (CAD) associated with abdominal obesity (AO).Material and methods. This 12-month prospective study included 68 patients diagnosed with CAD who were hospitalized for elective percutaneous coronary intervention (PCI). The median age was 61 [55;65] years. Depending on the presence of obesity according to the World Health Organization (1999) criteria, patients were divided into 2 groups. The 1st group included 30 patients with AO, while the 2nd group — 38 patients without obesity. Patients were measured for waist circumference and hip circumference, and waist-to-hip ratio was calculated. Lipid profile and NGAL concentration were determined. During the study, body mass index (BMI), visceral adiposity index (VAI), triglycerides (TG)/glucose index, lipid accumulation product (LAP), metabolic index (MI), TG to high-density lipoprotein cholesterol ratio (HDL-C). During this period, data was collected on the disease course and intervention outcome. After 12 months an extended examination was performed to assess the endpoints.Results. During the follow-up period, unfavorable cardiovascular events in the 1st group of patients were registered in 33,3% of patients, and in the 2nd group — in 26,3%. In the group of patients with obesity, higher values of anthropometric indices and NGAL were established. The concentration of NGAL has the highest correlation with BMI, MI, LAP and slightly less with total cholesterol and VAI levels. The analysis showed that NGAL >47,1 ng/ml is a predictor of adverse CVEs in patients with CAD and obesity after PCI.Conclusion. Thus, NGAL has the highest correlation with the following indices: BMI, MI, LAP, total cholesterol, and VAI. NGAL >47,1 ng/ml is a predictor of adverse CVEs in patients with CAD and obesity after PCI. NGAL may serve as a promising marker for predicting adverse CVEs. This biomarker already at the stage of hospitalization can assess the risk adverse outcomes in patients with CAD and AO, including those who underwent PCI.https://russjcardiol.elpub.ru/jour/article/view/5416neutrophil gelatinase-associated lipocalinabdominal obesitycoro¬nary artery disease |
| spellingShingle | A. V. Svarovskaya P. A. Astanin A/ T. Teplyakov A. D. Vende O. N. Ogurkova A. A. Garganeeva Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity Российский кардиологический журнал neutrophil gelatinase-associated lipocalin abdominal obesity coro¬nary artery disease |
| title | Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity |
| title_full | Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity |
| title_fullStr | Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity |
| title_full_unstemmed | Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity |
| title_short | Prognostic role of neutrophil gelatinase-associated lipocalin in patients with coronary artery disease and abdominal obesity |
| title_sort | prognostic role of neutrophil gelatinase associated lipocalin in patients with coronary artery disease and abdominal obesity |
| topic | neutrophil gelatinase-associated lipocalin abdominal obesity coro¬nary artery disease |
| url | https://russjcardiol.elpub.ru/jour/article/view/5416 |
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