Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury
Changes in the peroxisome proliferator-activated receptors-δ (PPARδ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and PPARδ in SCI remains unknown. In th...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2014/456386 |
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| author | Cheng-Chia Tsai Kung-Shing Lee Sheng-Hsien Chen Li-Jen Chen Keng-Fan Liu Juei-Tang Cheng |
| author_facet | Cheng-Chia Tsai Kung-Shing Lee Sheng-Hsien Chen Li-Jen Chen Keng-Fan Liu Juei-Tang Cheng |
| author_sort | Cheng-Chia Tsai |
| collection | DOAJ |
| description | Changes in the peroxisome proliferator-activated receptors-δ (PPARδ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and PPARδ in SCI remains unknown. In the present study, we used compressive SCI in streptozotocin-(STZ-) induced diabetic rats. GW0742, a PPARδ agonist, was used to evaluate its merit in STZ rats after SCI. Changes in PPARδ expression were detected by Western blot. Survival rates were also estimated. A lower expression of PPARδ in spinal cords of STZ-diabetic rats was observed. In addition, the survival times in two-week induction diabetes were longer than those in eight-week induction group, which is consistent with the expression of PPARδ in the spinal cord. Moreover, GW0742 significantly increased the survival time of STZ rats. Furthermore, their motor function and pain response were attenuated by GSK0660, a selective PPARδ antagonist, but were enhanced by GW0742. In conclusion, the data suggest that higher mortality rate in STZ-diabetic rats with SCI is associated with the decrease of PPARδ expression. Thus, change of PPARδ expression with the progress of diabetes seems responsible for the higher mortality rate after SCI. |
| format | Article |
| id | doaj-art-20f7b3748e234105a9fb9db6c2508e5b |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-20f7b3748e234105a9fb9db6c2508e5b2025-02-03T07:26:13ZengWileyPPAR Research1687-47571687-47652014-01-01201410.1155/2014/456386456386Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord InjuryCheng-Chia Tsai0Kung-Shing Lee1Sheng-Hsien Chen2Li-Jen Chen3Keng-Fan Liu4Juei-Tang Cheng5Department of Neurosurgery, Mackay Memorial Hospital, Taipei City 10449, TaiwanDepartment of Surgery, Kaohsiung Municipal Hsiao-Kang Hospital and Kaohsiung Medical University, Kaohsiung City 81201, TaiwanDepartment of Obstetrics and Gynecology, Chi Mei Medical Center, Yong Kang, Tainan City 71101, TaiwanInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City 70101, TaiwanInstitute of Medical Science, College of Health Science, Chang Jung Christian University, Gui-Ren, Tainan City 71301, TaiwanDepartment of Medical Research, Chi Mei Medical Center, Yong Kang, Tainan City 71101, TaiwanChanges in the peroxisome proliferator-activated receptors-δ (PPARδ) expression in rats after spinal cord injury (SCI) have been previously reported. Diabetic animals show a higher mortality after SCI. However, the relationship between the progress of diabetes and PPARδ in SCI remains unknown. In the present study, we used compressive SCI in streptozotocin-(STZ-) induced diabetic rats. GW0742, a PPARδ agonist, was used to evaluate its merit in STZ rats after SCI. Changes in PPARδ expression were detected by Western blot. Survival rates were also estimated. A lower expression of PPARδ in spinal cords of STZ-diabetic rats was observed. In addition, the survival times in two-week induction diabetes were longer than those in eight-week induction group, which is consistent with the expression of PPARδ in the spinal cord. Moreover, GW0742 significantly increased the survival time of STZ rats. Furthermore, their motor function and pain response were attenuated by GSK0660, a selective PPARδ antagonist, but were enhanced by GW0742. In conclusion, the data suggest that higher mortality rate in STZ-diabetic rats with SCI is associated with the decrease of PPARδ expression. Thus, change of PPARδ expression with the progress of diabetes seems responsible for the higher mortality rate after SCI.http://dx.doi.org/10.1155/2014/456386 |
| spellingShingle | Cheng-Chia Tsai Kung-Shing Lee Sheng-Hsien Chen Li-Jen Chen Keng-Fan Liu Juei-Tang Cheng Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury PPAR Research |
| title | Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury |
| title_full | Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury |
| title_fullStr | Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury |
| title_full_unstemmed | Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury |
| title_short | Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury |
| title_sort | decrease of pparδ in type 1 like diabetic rat for higher mortality after spinal cord injury |
| url | http://dx.doi.org/10.1155/2014/456386 |
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