Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion
Objective: Lumbar spinal fusion is a common procedure for treating spinal degenerative diseases. Percutaneous endoscopic lumbar interbody fusion (PELIF) is a minimally invasive technique that has gained popularity. However, the factors influencing fusion success rates after PELIF have not been well-...
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| Language: | English |
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AVES
2024-11-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | https://www.aott.org.tr/en/assessment-of-factors-implicated-in-bone-fusion-after-percutaneous-endoscopic-lumbar-intervertebral-fusion-137438 |
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| author | Zheng Huang Xialin Li Weihong Yi Junfeng Gong Yue Zhou Yu Tang |
| author_facet | Zheng Huang Xialin Li Weihong Yi Junfeng Gong Yue Zhou Yu Tang |
| author_sort | Zheng Huang |
| collection | DOAJ |
| description | Objective: Lumbar spinal fusion is a common procedure for treating spinal degenerative diseases. Percutaneous endoscopic lumbar interbody fusion (PELIF) is a minimally invasive technique that has gained popularity. However, the factors influencing fusion success rates after PELIF have not been well-studied.
Methods: This single-center retrospective study reviewed the medical records of 96 patients who underwent single-level PELIF for degenerative pathologies between 2018 and 2020. Fusion was evaluated using thin-slice computed tomography scans at 12 months by 2 independent radiologists and defined as no detectable lucency between bone and graft. Patients were categorized into fusion and non-fusion groups. Data on age, operative time, blood loss, drainage, hospital stay, surgical level, osteoporosis, endplateitis, body mass index, lumbar curvature, and bone morphogenetic protein (BMP) use were collected. Univariate tests (chi-square, Student’s t-test, and analysis of variance) were employed to compare factors between groups. Significant factors were included in a multivariate logistic regression model with fusion as the dependent variable.
Results: The overall fusion success rate was 85.6% (86 fusion and 10 non-fusion). Univariate analysis revealed significant di!erences in age, osteoporosis, hypertension, diabetes, endplateitis, and BMP use between groups. Multivariate analysis identified osteoporosis (odds ratio (OR)=5.44, 95% CI, P < .05) and end-plate osteochondritis (OR=10.449, 95% CI, P < .05) as independent risk factors for non-fusion.
Conclusion: The use of BMP and endplateitis are significant factors that a!ect bone fusion outcomes after the PELIF procedure. These factors should be taken into account in order to improve postoperative bone fusion.
Level of Evidence: Level IV, Therapeutic Study |
| format | Article |
| id | doaj-art-20e5b16830104571b0b673a5e9e226ed |
| institution | Kabale University |
| issn | 1017-995X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj-art-20e5b16830104571b0b673a5e9e226ed2025-02-03T13:04:49ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2024-11-0158635335710.5152/j.aott.2024.23142Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusionZheng Huang0https://orcid.org/0000-0002-8857-3166Xialin Li1https://orcid.org/0000-0003-3313-9263Weihong Yi2Junfeng Gong3https://orcid.org/0009-0002-8663-1956Yue Zhou4https://orcid.org/0009-0005-3951-6148Yu Tang5Department of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, Guangdong, ChinaDepartment of Orthopedics, Xinqiao Hospital a!liated to Army Military Medical University, Chongqing, ChinaDepartment of Orthopedics, Xinqiao Hospital a!liated to Army Military Medical University, Chongqing, ChinaDepartment of Orthopedics, Xinqiao Hospital a!liated to Army Military Medical University, Chongqing, ChinaObjective: Lumbar spinal fusion is a common procedure for treating spinal degenerative diseases. Percutaneous endoscopic lumbar interbody fusion (PELIF) is a minimally invasive technique that has gained popularity. However, the factors influencing fusion success rates after PELIF have not been well-studied. Methods: This single-center retrospective study reviewed the medical records of 96 patients who underwent single-level PELIF for degenerative pathologies between 2018 and 2020. Fusion was evaluated using thin-slice computed tomography scans at 12 months by 2 independent radiologists and defined as no detectable lucency between bone and graft. Patients were categorized into fusion and non-fusion groups. Data on age, operative time, blood loss, drainage, hospital stay, surgical level, osteoporosis, endplateitis, body mass index, lumbar curvature, and bone morphogenetic protein (BMP) use were collected. Univariate tests (chi-square, Student’s t-test, and analysis of variance) were employed to compare factors between groups. Significant factors were included in a multivariate logistic regression model with fusion as the dependent variable. Results: The overall fusion success rate was 85.6% (86 fusion and 10 non-fusion). Univariate analysis revealed significant di!erences in age, osteoporosis, hypertension, diabetes, endplateitis, and BMP use between groups. Multivariate analysis identified osteoporosis (odds ratio (OR)=5.44, 95% CI, P < .05) and end-plate osteochondritis (OR=10.449, 95% CI, P < .05) as independent risk factors for non-fusion. Conclusion: The use of BMP and endplateitis are significant factors that a!ect bone fusion outcomes after the PELIF procedure. These factors should be taken into account in order to improve postoperative bone fusion. Level of Evidence: Level IV, Therapeutic Studyhttps://www.aott.org.tr/en/assessment-of-factors-implicated-in-bone-fusion-after-percutaneous-endoscopic-lumbar-intervertebral-fusion-137438 |
| spellingShingle | Zheng Huang Xialin Li Weihong Yi Junfeng Gong Yue Zhou Yu Tang Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion Acta Orthopaedica et Traumatologica Turcica |
| title | Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion |
| title_full | Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion |
| title_fullStr | Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion |
| title_full_unstemmed | Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion |
| title_short | Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion |
| title_sort | assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion |
| url | https://www.aott.org.tr/en/assessment-of-factors-implicated-in-bone-fusion-after-percutaneous-endoscopic-lumbar-intervertebral-fusion-137438 |
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